Table 14, KQ2 summary of findings and strength of evidence for other pharmacological agents - ADHD Diagnosis and Treatment in Children and Adolescents

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Intervention and Comparison	Outcome	Number of Studies; Study Design and IDs	Findings	Reasons for Downgrading	SoE
KQ2 modafinil vs control	Broadband measures	3 RCTs¹⁴⁶^, ¹⁴⁷^, ³⁰⁴	No systematic effect detected (RR 0.49; CI 0.12, 2.07; 3 studies, n=539).	S	Low for no effect
KQ2 modafinil vs control	ADHD symptoms	4 RCTs RCTs¹⁴⁷^, ³⁰⁴^, ³⁵⁴^, ⁵⁷⁴	All individual studies were positive, but the pooled effect was not statistically significant due to the wide variation in effects (SMD −0.76; CI −1.75, 0.23; 4 studies, n=667; RR 37.00; CI 2.36, 578.24; 1 study, n=46)	I	Insufficient
KQ2 modafinil vs control	Appetite suppression	5 RCTs¹⁴⁶^, ¹⁴⁷^, ³⁰⁴^, ³⁵⁴^, ⁵⁷⁴	Intervention was associated with an effect (RR 4.44; CI 2.27, 8.69; 5 studies; n=780)	I	Moderate for effect
KQ2 ABT-089 vs control	Broadband measures	2 RCTs¹⁰⁵^, ⁶²⁰	No meaningful summary estimate could be derived (SMD 0.02, CI −2.58, 2.53; 2 studies, n=168)	S, I	Insufficiefine ent
KQ2 ABT-089 vs control	Number of participants reporting on the event	2 RCTs¹⁰⁵^, ⁶²⁰	No systematic effect (RR 0.90; CI 0.64, 1.25; 2 studies, n=171)	S, I	Low for no effect

: Notes: CI = 95% confidence interval, I = imprecision, KQ = Key Question, RCT = randomized controlled trial, RR = relative risk, S = study limitation, SMD = standardized mean differences, SoE = strength of evidence

ADHD Diagnosis and Treatment in Children and Adolescents [Internet].

Comparative Effectiveness Review, No. 267.

Peterson BS, Trampush J, Maglione M, et al.

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