Table 25, KQ2a summary of findings and strength of evidence for ADHD interventions - ADHD Diagnosis and Treatment in Children and Adolescents - NCBI Bookshelf

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Table 25KQ2a summary of findings and strength of evidence for ADHD interventions

Intervention and Comparison	Outcome	Number of Studies; Study	Findings	Reasons for Downgrading	SoE
KQ2a effect modifier ADHD presentation	Behavior	N/A	Indirect comparisons did not suggest an effect	D	Low for no effect
KQ2a effect modifier ADHD presentation	Broadband measures	N/A	Indirect comparisons did not suggest an effect	D	Low for no effect
KQ2a effect modifier ADHD presentation	ADHD symptoms	N/A	Indirect comparisons did not suggest an effect	D	Low for no effect
KQ2a effect modifier ADHD presentation	Functional impairment	N/A	Indirect comparisons did not suggest an effect	D	Low for no effect
KQ2a effect modifier ADHD presentation	Acceptability of treatment	N/A	Indirect comparisons did not suggest an effect	D	Low for no effect
KQ2a effect modifier ADHD presentation	Academic performance	N/A	Indirect comparisons did not suggest an effect	D	Low for no effect
KQ2a effect modifier ADHD presentation	Appetite suppression	N/A	Indirect comparisons did not suggest an effect	D	Low for no effect
KQ2a effect modifier ADHD presentation	Participants with adverse events	N/A	Indirect comparisons reported conflicting results	D, C	Insufficient
KQ2a effect modifiers co-occurring disorders	Behavior	N/A	Indirect comparisons did not detect effects, but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2a effect modifiers presentation and co-occurring disorders	Broadband measures	N/A	Indirect comparisons did not detect effects, but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2a effect modifiers presentation and co-occurring disorders	ADHD symptoms	N/A	Indirect comparisons did not detect effects, but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2a effect modifiers presentation and co-occurring disorders	Functional impairment	N/A	Indirect comparisons did not detect effects, but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2a effect modifiers presentation and co-occurring disorders	Acceptability of treatment	N/A	Indirect comparisons did not detect effects, but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2a effect modifiers presentation and co-occurring disorders	Academic performance	N/A	Indirect comparisons did not detect effects, but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2a effect modifiers presentation and co-occurring disorders	Appetite suppression	N/A	Indirect comparisons did not detect effects, but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2a effect modifiers presentation and co-occurring disorders	Participants with adverse events	N/A	Indirect comparisons did not detect effects but few studies addressed co-occurring disorders systematically	D, C	Insufficient
KQ2b diversion	Misuse	2 studies⁴⁵⁵^, ⁴⁹⁷	Did not indicate any issues	D, C	Insufficient

: Notes: ADHD = attention deficit hyperactivity disorder, C = inconsistency, D = indirectness, KQ = Key Question, N/A = not applicable, SoE = strength of evidence

From: 5, Results: Treatment of ADHD

Cover of ADHD Diagnosis and Treatment in Children and Adolescents

ADHD Diagnosis and Treatment in Children and Adolescents [Internet].

Comparative Effectiveness Review, No. 267.

Peterson BS, Trampush J, Maglione M, et al.

Rockville (MD): Agency for Healthcare Research and Quality (US); 2024 Mar.

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