| KQ1 Diagnostic Test | Outcome | Number of Studies and IDs | Findings | Reasons for Downgrading | SoE |
|---|---|---|---|---|---|
| KQ1 Biomarkers (biospecimen) | Sensitivity | 7 studies309, 501, 563, 583, 603, 635, 644 | Sensitivity ranged from 56% (corresponding specificity 95%)501 to100% (corresponding specificity 100%) using a serum marker309 differentiating ADHD and neurotypical development | S, I | Low |
| KQ1 Blood biomarkers | Sensitivity | 2 studies309, 563 | Sensitivity ranged from 79% (corresponding specificity 25%)563 to 100% (corresponding specificity 100%) using a serum marker309 | S, I | Low |
| KQ1 miRNA biomarkers | Sensitivity | 3 studies603, 635, 644 | Sensitivity ranged from 68% (corresponding specificity 71%)635 to 90% (corresponding specificity 80%)603 | S, I | Low |
| KQ1 urine markers | Sensitivity | 2 studies501, 583 | Sensitivity ranged from 56% (corresponding specificity 95%)501 to 94% (corresponding specificity 83%)583 | S, I | Low |
| KQ1 Biomarkers (biospecimen) | Specificity | 7 studies309, 501, 563, 583, 603, 635, 644 | Specificity ranged from 25% (corresponding sensitivity 79%)563 to 100% (corresponding sensitivity 100%) using a serum marker309 differentiating ADHD and neurotypical development | S, I | Low |
| KQ1 Blood biomarkers | Specificity | 2 studies309, 563 | Specificity ranged from 25% (corresponding sensitivity 79%)563 to 100% (corresponding sensitivity 100%)309 | S, I | Low |
| KQ1 miRNA biomarkers | Specificity | 3 studies603, 635, 644 | Specificity ranged from 71% (corresponding specificity 68%)635 to 95% (corresponding sensitivity 82%)635 | S, I | Low |
| KQ1 urine markers | Specificity | 2 studies501, 583 | Specificity ranged from 80% (corresponding sensitivity 88%)501 to 95% (corresponding sensitivity 56%)501 | S, I | Low |
| KQ1 Biomarkers (biospecimen) | Accuracy | 2 studies563, 603 | Accuracy ranged from 55% using a blood marker563 to 85% using miRNA603 differentiating ADHD and neurotypical development | S, C | Low |
| KQ1 Biomarkers (biospecimen) | AUC | 4 studies309, 583, 603, 644 | AUC ranged from 0.68603 using mIRNA635 to 1.00309 using a serum marker differentiating ADHD and neurotypical development | S, C | Low |
| KQ1 Biomarkers (biospecimen) | Rater agreement | 0 studies | No data | C | Insufficient |
| KQ1 Biomarkers (biospecimen) | Internal consistency | 0 studies | No data | C | Insufficient |
| KQ1 Biomarkers (biospecimen) | Test-retest reliability | 0 studies | No data | C | Insufficient |
| KQ1 Biomarkers (biospecimen) | Misdiagnosis impact | 0 studies | No data | C | Insufficient |
Notes: ADHD = attention deficit hyperactivity disorder, AUC = area under the curve, C = inconsistency, I = imprecision, Key Question = Key Question, S = study limitation, SoE = strength of evidence
From: 4, Results: Diagnosis of ADHD
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