| Aksoy et al. (2023)15 Turkey Funding: Study authors did not receive financial support or funding. | Double-blind, 3-arm RCT with 2 arms relevant for this report. Single centre. Participants randomized in a 1:1:1 ratio via a computer-aided random number chart. | Singleton pregnant womena who had been scheduled for elective Caesarean delivery. N, randomized = 105 IV paracetamol, n = 35 Placebo, n = 35 Age (years), mean(SD) IV paracetamol = 26.69(6.45) Placebo = 29.51(5.38) | Intervention: IV paracetamol 1 g in 100 mL for infusion Comparator: Placebo (subcutaneous 20 mL and IV saline) All participants received their intervention after Caesarean delivery and after every 6 hours for 24 hours. | Outcome: Total morphine consumption Length of follow up: NR Opioids: Morphine through PCA |
| Westrich et al. (2019)14 US Funding source: Mallinckrodt Pharmaceuticals and the Hospital for Special Surgery, Research and Education Fund. | Double-blind, 2-arm RCT, Single centre. Participants randomized in a 1:1 ratio block of size 6 and 8 via a computer generated randomization schedule. | Individuals aged 18 to 90 years old scheduled for an elective primary unilateral total hip arthroplasty using a posterior approach. N, randomized = 154 IV acetaminophen, n = 77 Oral acetaminophen, n = 77 Age (years), median (SD) IV acetaminophen = 63(10) Oral acetaminophen = 65(10) Sex (male %) IV acetaminophen = 36.4% Oral acetaminophen = 45.5% Pain at rest, numerical rating scale, mean (SD) IV acetaminophen = 3.9(2.6) Oral acetaminophen = 4.2(2.6) Pain at ambulation, numerical rating scale, mean (SD) IV acetaminophen = 6.5(2.5) Oral acetaminophen = 6.7(2.4) |
Intervention:
15 minute infusion of 1g of IV acetaminophen (Ofirmev) in a 100 mL solution with oral placebo (2 capsules)
Comparator: Oral acetaminophen (1 g in 2 capsules) with IV placebo (100 mL saline)
All study arms received their assignment 30 minutes after admission to postanesthesia care unit.
| Outcome and length of follow up: Cumulative opioid usage between postoperative day 0 and day 3 (measured as opioid consumption in mg of oral morphine equivalent) Opioids: 50 mg of tramadol for mild pan, 100 mg of tramadol for moderate pain, 5 mg of oxycodone for severe pain, 10/15 mg of oxycodone as needed. |
