Table 7Changes From Baseline in Patient-Reported Outcomes Over 2 Years, Shown as Mean (95% CI)a

VariableUCILIDifference
Change in PROMIS-29 Physical Functioningb
 6 mo−0.17 (−1.12 to 0.78)1.96 (1.02-2.90)2.13 (0.94-3.32)
 12 mo−0.33 (−1.30 to 0.65)1.23 (0.26-2.19)1.55 (0.32-2.78)
 24 mo−0.39 (−1.39 to 0.62)0.82 (−0.16 to 1.79)1.20 (−0.06 to 2.46)
Change in PROMIS-29 Anxietyc
 6 mo0.39 (−0.96 to 1.74)−1.51 (−2.84 to −0.19)−1.90 (−3.61 to −0.19)
 12 mo−0.29 (−1.62 to 1.04)−0.89 (−2.20 to 0.41)−0.60 (−2.28 to 1.07)
 24 mo−0.53 (−1.95 to 0.89)−0.92 (−2.29 to 0.46)−0.39 (−2.18 to 1.41)
Change in PROMIS-29 Depressionc
 6 mo0.73 (−0.19 to 1.65)−0.06 (−1.00 to 0.87)−0.79 (−1.93 to 0.35)
 12 mo0.80 (−0.13 to 1.74)0.29 (−0.67 to 1.24)−0.52 (−1.69 to 0.66)
 24 mo0.64 (−0.34 to 1.63)−0.18 (−1.17 to 0.81)−0.82 (−2.07 to 0.42)
Change in PROMIS-29 Fatiguec
 6 mo−0.98 (−2.13 to 0.17)−3.49 (−4.64 to −2.33)−2.51 (−3.94 to −1.07)
 12 mo−1.23 (−2.43 to −0.04)−2.60 (−3.80 to −1.40)−1.36 (−2.87 to 0.15)
 24 mo−1.03 (−2.28 to 0.22)−2.82 (−4.06 to −1.59)−1.80 (−3.37 to −0.22)
Change in PROMIS-29 Sleep Disturbancec
 6 mo0.23 (−0.93 to 1.39)−2.01 (−3.15 to −0.87)−2.24 (−3.69 to −0.78)
 12 mo−0.02 (−1.25 to 1.21)−0.88 (−2.08 to 0.32)−0.86 (−2.42 to 0.70)
 24 mo−0.35 (−1.59 to 0.89)−1.25 (−2.45 to −0.05)−0.90 (−2.47 to 0.67)
Change in PROMIS-29 Social Functioningb
 6 mo0.05 (−0.87 to 0.98)2.14 (1.19-3.08)2.08 (0.95-3.22)
 12 mo0.46 (−0.52 to 1.45)1.97 (0.96-2.97)1.50 (0.27-2.74)
 24 mo0.15 (−0.87 to 1.17)1.57 (0.55-2.60)1.42 (0.14-2.71)
Change in PROMIS-29 Pain Interferencec
 6 mo−0.04 (−1.07 to 0.98)−1.58 (−2.63 to −0.53)−1.54 (−2.80 to −0.28)
 12 mo0.46 (−0.63 to 1.55)−0.95 (−2.06 to 0.16)−1.41 (−2.78 to −0.05)
 24 mo0.21 (−0.95 to 1.37)−1.06 (−2.22 to 0.10)−1.27 (−2.72 to 0.19)
Change in PROMIS-29 Pain Intensityc,d
 6 mo0.02 (−0.28 to 0.31)−0.26 (−0.56 to 0.05)−0.27 (−0.64 to 0.10)
 12 mo0.07 (−0.25 to 0.40)−0.01 (−0.33 to 0.32)−0.08 (−0.49 to 0.33)
 24 mo0.21 (−0.12 to 0.53)−0.02 (−0.35 to 0.30)−0.23 (−0.64 to 0.18)
Change in weight-related QOL (IWQOL-L total score)e
 6 mo3.02 (1.14-4.90)10.55 (8.69-12.41)7.53 (5.18-9.88)
 12 mo3.56 (1.61-5.50)11.14 (9.23-13.06)7.59 (5.15-10.03)
 24 mo4.36 (2.34-6.39)11.02 (9.04-13.00)6.66 (4.10-9.21)
Change in IWQOL-L physical functione
 6 mo2.71 (−0.03 to 5.45)13.35 (10.70-16.00)10.64 (7.17-14.10)
 12 mo3.20 (0.44-5.96)13.59 (10.92-16.27)10.39 (6.89-13.89)
 24 mo4.11 (1.24-6.97)12.31 (9.55-15.06)8.20 (4.56-11.84)
Change in IWQOL-L self-esteeme
 6 mo4.69 (2.20-7.17)12.20 (9.67-14.72)7.51 (4.44-10.58)
 12 mo5.86 (3.21-8.50)13.74 (11.07-16.40)7.88 (4.57-11.19)
 24 mo7.62 (4.88-10.36)14.39 (11.66-17.12)6.77 (3.32-10.21)
Change in IWQOL-L sexual lifee
 6 mo2.02 (−1.05 to 5.08)12.19 (9.05-15.33)10.18 (6.37-13.98)
 12 mo3.19 (0.12-6.27)12.20 (9.04-15.36)9.01 (5.18-12.84)
 24 mo4.49 (1.18-7.80)14.32 (11.00-17.65)9.83 (5.68-13.99)
Change in IWQOL-L public distresse
 6 mo2.42 (−0.12 to 4.96)4.76 (2.29-7.22)2.33 (−0.88 to 5.54)
 12 mo2.39 (−0.19 to 4.96)5.95 (3.46-8.44)3.56 (0.31-6.82)
 24 mo2.41 (−0.20 to 5.02)5.38 (2.86-7.89)2.97 (−0.34 to 6.27)
Change in IWQOL-L work/daily activitye
 6 mo2.69 (0.57-4.82)5.41 (3.29-7.53)2.72 (0.07-5.37)
 12 mo1.83 (−0.38 to 4.03)5.67 (3.48-7.86)3.84 (1.08-6.60)
 24 mo1.47 (−0.83 to 3.76)5.48 (3.22-7.75)4.02 (1.12-6.91)

Abbreviations: ILI, intensive lifestyle intervention; IWQOL-L, Impact of Weight on Quality of Life–Lite; PROMIS, Patient-Reported Outcomes Measurement Information System; QOL, quality of life; UC, usual care.

aAnalyzed using multilevel mixed-effects linear regression. All models included age, sex, and race as covariates. The 95% CIs that do not include 0 indicate a statistically significant result.

bA positive change score indicates improvement, while a negative change score indicates worsening from baseline.

cA negative change score indicates improvement, while a positive change score indicates worsening from baseline.

dOn a scale of 0 to 10, in which a higher score reflects more pain.

eHigher change scores indicate greater improvement from baseline.

From: Testing a Health Coaching Program to Help Patients with Obesity Lose Weight—The PROPEL Study

Cover of Testing a Health Coaching Program to Help Patients with Obesity Lose Weight—The PROPEL Study
Testing a Health Coaching Program to Help Patients with Obesity Lose Weight—The PROPEL Study [Internet].
Katzmarzyk PT, Martin CK, Newton RL Jr, et al.
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