Table 2Electrophysiological characteristics of motoneuron clusters in adult mice

Cluster 1Cluster 2Cluster 3Cluster 4
Passive
RMP (mV)–70.3–68.8–74.2–70.6
Input Resistance (mOhm)95.473.448.043.8
Membrane time constant (ms)8.96.94.92.2
SAG ratio (h current)18.911.018.23.7
Active (500 ms square pulse)
FIF (Hz) Instantaneous firing, beginning of the pulse 45.9164.8 (doublet action potentials)340.6424.0
SSF (Hz) Steady-state firing end of the pulse 31.950.374.6147.7
Muscle innervation
Muscle SoleusSoleusTibialis AnteriorTibialis Anterior
Fiber type Slow twitch fiberSlow twitch fiberFast twitch fiberFast twitch fiber

Motoneuron subtypes were defined using cluster analysis and functional identity was achieved with retrograde labeling of known muscle types (38). Soleus: slow-twitch fiber type and Tibialis anterior: fast-twitch fiber type. RMP, resting membrane potential; FIF, firing frequency; SSF, steady-state firing.

From: Chapter 4, Synaptic Transmission and Motoneuron Excitability Defects in Amyotrophic Lateral Sclerosis

Cover of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis [Internet].
Araki T, editor.
Brisbane (AU): Exon Publications; 2021 Jul 25.
Copyright: The Authors.

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