Table 6.

Recommended Surveillance for Individuals with RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies

System/ConcernEvaluationFrequency
Hematologic
malignancy 		Clinical exam for constitutional signs & symptoms of neoplasm (e.g., fatigue, unexplained fever, unexplained weight loss, shortness of breath)Every 6-12 mos or more frequently as clinically indicated
CBC w/differentialEvery 3-4 mos
Bone marrow exam
  • If constitutional symptoms &/or abnormalities on CBC are identified
  • Consider annually (although there is no consensus on this recommendation).
Eczema Skin examAs needed

CBC = complete blood count

From: RUNX1 Familial Platelet Disorder with Associated Myeloid Malignancies

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