| Time After Starting | Time After Stopping | ALT* (U/L) | Alk P (U/L) | Bilirubin* (mg/dL) | Other |
|---|---|---|---|---|---|
| 6 weeks | 0 | 905 | 121 | 4.8 | ANA: 1:320 |
| 7 weeks | 1 week | 960 | 4.5 | Liver biopsy | |
| 8 weeks | 2 weeks | 1160 | 3.0 | ||
| 9 weeks | 3 weeks | 1080 | 3.0 | ||
| 3 months | 6 weeks | 280 | 4.0 | ||
| 4 months | 10 weeks | 120 | |||
| 12 weeks | 40 | 1.0 | |||
| Metformin restarted approximately 4 months later | |||||
| 12 weeks | 0 | 880 | 3.0 | ||
| 13 weeks | 1 week | 1240 | 2.5 | ANA still present | |
| 14 weeks | 2 | 1120 | 2.2 | ||
| 15 weeks | 3 | 920 | 2.1 | ||
| 4 months | 4 | 800 | 2.5 | ||
| 5 months | 9 | 480 | 1.0 | ||
| 6 months | 13 | 40 | 1.0 | ||
| Normal Values | <40 | <130 | <1.2 | ||
Values of ALT and bilirubin were estimated from the figure and converted from times upper limit of normal to absolute values based upon normal values provided.
From: Metformin
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