| Time After Starting | Time After Stopping | AST* (U/L) | Alk P* (U/L) | Bilirubin (mg/dL) | Other |
|---|---|---|---|---|---|
| Bosentan 125 mg twice daily started | |||||
| 0 | Pre | 42 | 1.2 | ||
| 1 month | 36 | 1.0 | |||
| 6 months | 24 | 1.1 | |||
| 12 months | 30 | 1.3 | |||
| 16 months | 42 | 1.3 | |||
| 18 months | Admitted for jaundice; bosentan stopped | ||||
| 18 months | 0 | 840 | 480 | 9.6 | INR 1.52 |
| 3 days | 870 | 12.0 | |||
| 6 days | 900 | 14.6 | INR 1.8 | ||
| 9 days | 660 | 17.5 | Prednisolone started | ||
| 11 days | 408 | 11.1 | |||
| 12 days | 210 | 8.2 | |||
| 15 days | 60 | 7.3 | Discharged | ||
| 22 days | 24 | 3.5 | |||
| 19 months | 4 weeks | 42 | 2.6 | ||
| 6 weeks | 24 | 1.4 | Prednisolone stopped | ||
| 20 months | 2 months | 24 | 0.8 | ||
| Normal Values | <55 | <110 | <1.2 | ||
From: Bosentan
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