Table 5. [Treatment of Manifestations in Individuals with EFEMP2-Related Cutis Laxa]. - GeneReviews®

Manifestation/ Concern	Treatment
Arterial dilatation/ aneurysm	Based on experience in related disorders (e.g., Marfan syndrome), treatment w/beta-blockers or angiotensin receptor blockers can be considered when aortic root dilatation is present. Surgical repair of large aortic aneurysms (at risk for dissection) should be considered. Aortic aneurysm replacement has been performed successfully.
Pulmonary emphysema	Treated symptomatically
Micrognathia	Tracheostomy may be necessary when retrognathia leads to upper airway obstruction.
Joint hypermobility	Muscle-strengthening PT
Hernia	Routine surgical repair

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