Table 4.

Treatment of Manifestations in Individuals with EDD-Related Overgrowth

Manifestation/ConcernTreatmentConsiderations/Other
Developmental delay /
intellectual disability 		Early referral for developmental support / special educationSee text following this table.
Seizure disorder Standard treatment per neurologistSee footnote 1.
Cervical spine instability Surgical intervention if instability is severe & neurologic compromise is present or likelyExpert neurosurgical advice recommended, particularly for prophylactic intervention
Cleft palate Mgmt by cleft/craniofacial team; surgical correction of cleft palate; orthodontic interventions to correct retrognathia (overbite) as needed
Scoliosis/kyphosis Standard treatment per orthopedist
Congenital heart defects Standard therapy per cardiologist
Undescended testes, inguinal hernia Standard treatment per urologist
Strabismus, refractive error, cataracts Standard treatment per ophthalmologist
Hyperinsulinemic hypoglycemia Glucose; consider octreotide.Endocrine eval recommended if hypoglycemia persists &/or insulin levels ↑
Joint contractures &/or hypertonia Physiotherapy/surgery as needed
1.

Education of parents regarding common seizure presentations is appropriate. For information on non-medical interventions and coping strategies for parents or caregivers of children diagnosed with epilepsy, see Epilepsy Foundation Toolbox.

From: EED-Related Overgrowth

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