Table 6.

Treatment of Manifestations in Individuals with FARS2 Deficiency: Later-Onset Spastic Paraplegia

Manifestation/
Concern		TreatmentConsiderations/Other
Spasticity Orthopedics / physical medicine & rehab / PT & OT incl stretching to avoid contractures & fallsConsider need for positioning & mobility devices, disability parking placard.
  • Anti-spasticity medications (e.g., oral or intrathecal baclofen)
  • Botulinum toxin injections
  • Surgical interventions to ↓ spasticity
Seizures Treatment by experienced neurologist
  • Standard treatment w/ASM by experienced neurologist
  • See footnote 1.

ASM = anti-seizure medication; OT = occupational therapy; PT = physical therapy

1.

Education of parents regarding common seizure presentations is appropriate. For information on non-medical interventions and coping strategies for parents or caregivers of children diagnosed with epilepsy, see Epilepsy Foundation Toolbox.

From: FARS2 Deficiency

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