| Search | Query | Results |
|---|---|---|
| #1 | ‘rheumatoid arthritis’/exp OR ‘rheumatoid arthritis’ | 196,665 |
| #2 | ‘adrenal cortex hormones’ OR corticosteroid* | 282,225 |
| #3 | methylprednisolone OR prednisone OR prednisolone | 320,723 |
| #4 | hydroxychloroquine OR leflunomide OR methotrexate OR sulfasalazine | 173,827 |
| #5 | adalimumab OR ‘certolizumab pegol’ OR etanercept OR golimumab OR infliximab OR abatacept OR tocilizumab OR rituximab OR tofacitinib OR sarilumab OR Baricitinib OR sirukumab | 115,006 |
| #6 | amjevita OR inflectra OR erelzi | 168 |
| #7 | #2 OR #3 OR #4 OR #5 OR #6 | 703,322 |
| #8 | #1 AND #7 | 56,311 |
| #9 | #8 AND (‘editorial’/it OR ‘letter’/it) | 4,240 |
| #10 | #8 NOT #9 | 52,071 |
| #11 | #10 AND ([adult]/lim OR [aged]/lim OR [middle aged]/lim OR [very elderly]/lim OR [young adult]/lim) | 17,805 |
| #12 | #10 AND ([adult]/lim OR [aged]/lim OR [middle aged]/lim OR [very elderly]/lim OR [young adult]/lim) AND [humans]/lim AND [english]/lim | 15,753 |
| #13 | ‘randomized controlled trial’/exp OR ‘single blind procedure’/exp OR ‘double blind procedure’/exp OR ‘random allocation’/exp | 540,522 |
| #14 | ‘systematic review’/exp OR ‘systematic review (topic)’/exp OR ‘meta-analysis’/exp OR ‘meta analysis (topic)’/exp OR ‘meta analysis’/exp | 236,374 |
| #15 | ‘case control study’/exp OR ‘cohort analysis’/exp OR ‘epidemiological study’ OR ‘cross-sectional study’/exp OR ‘organizational case study’ OR ‘crossover procedure’/exp OR ‘seroepidemiologic study’ OR ‘epidemiology’/exp OR ‘multicenter study’/exp OR ‘multicenter study (topic)’/exp OR ‘evaluation research’/exp | 3,034,615 |
| #16 | #12 AND #13 | 1,426 |
| #17 | #12 AND #14 | 139 |
| #18 | #12 AND #15 | 4,073 |
| #19 | #16 AND [2010-2017]/py | 692 |
| #20 | #17 AND [2010-2017]/py | 113 |
| #21 | #18 AND [2010-2017]/py | 2,799 |
| #22 | #19 AND [medline]/lim | 456 |
| #23 | #20 AND [medline]/lim | 45 |
| #24 | #21 AND [medline]/lim | 1,659 |
| #25 | #19 NOT #22 | 236 |
| #26 | #20 NOT #23 | 68 |
| #27 | #21 NOT #24 | 1,140 |
| #28 | #25 OR #26 OR #27 | 1,312 |
From: Appendix A, Search Strings
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