Table 3.

Influence of Parental and Fetal Genotype on Fetal Growth and Recommended Management of the Mother during a Pregnancy at Risk for GCK-MODY

Source of GCK Pathogenic VariantFetal Growth and Recommended Management during Pregnancy: GCK Variant Present in Fetus? 1
YesNo
Fetal growthTreatmentFetal growth 2Treatment 3
Mother NormalNoneBirth weight >700 g compared to normal (i.e., fetus with maternal GCK variant)Insulin is recommended (dose required to ↓ mother's fasting glucose is > replacement dose).
Consider delivery at 38 wks' gestation when abdominal circumference >75th %ile.
Father (or
de novo) 		Restricted: birth weight 400 g < normalNoneNormalNone
1.

When the fetal genotype is not known, it can be inferred from abdominal circumference on second trimester fetal ultrasound.

2.

Assessed by second-trimester ultrasound [Spyer et al [2001]

3.

From: Maturity-Onset Diabetes of the Young Overview

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