Table 5.

Treatment of Manifestations in Individuals with KBG Syndrome

Manifestation/ConcernTreatmentConsiderations/Other
Palatal anomalies Surgical correction &/or speech therapy may be required.
Feeding issues Nasogastric tube during infancy or medication for GERD may be required.Refer to nutritionist or dietician as needed [Goldenberg et al 2016, Low et al 2016].
Seizures Treatment per neurologist based on type of seizure present [Lo-Castro et al 2013]
Undescended testes Standard treatment per urologist
Chronic otitis media Referral to otolaryngologist for consideration of pressure-equalizing tubes &/or tonsillectomy/adenoidectomy
Hearing loss Consider amplification.See Hereditary Hearing Loss and Deafness Overview.
Cardiovascular anomalies Standard treatment per cardiologist
Vision issues / strabismus Standard treatment per ophthalmologist
Short stature Consider growth hormone therapy.
Premature puberty Consider medication to arrest puberty, as per endocrinologist.

GERD = gastroesophageal reflux disease

From: KBG Syndrome

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