Table 5. [Prevention of Secondary Complications in Individuals with Pelizaeus-Merzbacher-Like Disease 1]. - GeneReviews®

Complication	Preventive Measure	Considerations/Other
Constipation	Dietary management, laxatives, stool softeners
Bone health	Regular monitoring of serum vitamin D & calcium levels	If osteopenia is documented, consult w/bone health clinic to consider measures to avoid fracture.
Community- acquired pneumonia	Good hand hygiene; influenza & pneumococcal vaccines	Some affected individuals are reported to have deterioration of neurologic function w/febrile illness & infection. ¹
Psychosocial consequences in caregiver	Involvement of social worker

From: Pelizaeus-Merzbacher-Like Disease 1

GeneReviews^® [Internet].

Adam MP, Feldman J, Mirzaa GM, et al., editors.

Seattle (WA): University of Washington, Seattle; 1993-2024.

GeneReviews® chapters are owned by the University of Washington. Permission is hereby granted to reproduce, distribute, and translate copies of content materials for noncommercial research purposes only, provided that (i) credit for source (http://www.genereviews.org/) and copyright (© 1993-2024 University of Washington) are included with each copy; (ii) a link to the original material is provided whenever the material is published elsewhere on the Web; and (iii) reproducers, distributors, and/or translators comply with the GeneReviews® Copyright Notice and Usage Disclaimer. No further modifications are allowed. For clarity, excerpts of GeneReviews chapters for use in lab reports and clinic notes are a permitted use.

For more information, see the GeneReviews® Copyright Notice and Usage Disclaimer.

For questions regarding permissions or whether a specified use is allowed, contact: ude.wu@tssamda.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.