Table 5.

Recommended Surveillance for Individuals with TRIO-Related Neurodevelopmental Disorder

System/ConcernEvaluationFrequency
Development Monitor developmental progress & educational needs.At each visit
Neurologic Assess for changes in seizures or new seizures.
Neurobehavioral/
Psychiatric 		Behavioral assessment for attention, aggression, &/or social communication difficulties
Feeding
  • Measurement of growth parameters
  • Eval of nutritional status & safety of oral intake
Gastrointestinal Assess for GERD & constipation.
Spine Assess for spine deformities.At each visit beginning in early childhood
Dental Dental examFrequency per dentist based on dental condition
Immunology Assess for frequent infections.At each visit
Family/Community Assess family need for social work support (e.g., palliative/respite care, home nursing, other local resources), care coordination, or follow-up genetic counseling if new questions arise (e.g., family planning).

GERD = gastroesophageal reflux disease

From: TRIO-Related Neurodevelopmental Disorder

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