Table 8.

Constructing queries.

ScopeQueryNotes

Find genes mapped to Arabidopsis thaliana chromosome 3 that have orthologs reported in HomoloGene

arabidopsis thaliana[orgn] AND 3[chr] AND gene_homologene[filter]

[orgn] is used to restrict “Arabidopsis thaliana” to the organism field.

[chr] is used to restrict ”3” to the chromosome field.
gene homologene[filter] is used to restrict records to those processed by HomoloGene.
This query is not currently able to be processed by Genome Data Viewer, because the relationship to HomoloGene is not processed for indexing at present, nor by HomoloGene, because the chromosome data are not captured in HomoloGene.

Find genes also being processed by OMIM but for which there is not currently a RefSeq of the type "known"

gene omim[filter] NOT srcdb refseq known[prop]

gene omim[filter] is used to find all Gene records with relationships to OMIM.
srcdb refseq known[prop] is used (as the Boolean NOT) to find all such records that do not have RefSeqs of the accession format NM_000000, NG_000000, or NR_000000.

Find genes from genomes other than mammals that are classified by the GO consortium to have some relationship to the cytoskeleton

cytoskeleton[go] NOT mammalia[orgn]

[go] is used to restrict to the field “Genome Ontology”.
[orgn] is used to restrict (as the Boolean NOT) to species not classified as mammals.
Queries based on GO terms are not supported in either Genome Data Viewer or HomoloGene. Please note that Gene does not recapitulate tree-based searching for GO annotation; this retrieval is based solely on the existence of the word in any GO category. Links are provided to the GO website to support more specific searches.

Find genes expressed in human placenta but not prostate

human[orgn] AND ("placenta"[expression/tissues] NOT "prostate"[expression/tissues])

[orgn] is used to restrict “human” to the organism field.

[expression/tissues] is used to restrict records to those expressed in placenta while the Boolean NOT also restricts it to those not expressed in prostate.

Find genes expressed in mouse liver

mouse[orgn] liver[expression/tissues]

[orgn] is used to restrict “mouse” to the organism field.

[expression/tissues] is used to restrict records to those expressed in liver at any of the 4 developmental stages represented in the primary mouse dataset. Expression bins are indexed both on the full string and individual words.

Find genes expressed in mouse liver at developmental stage E14.5

mouse[orgn] "liver E14.5"[expression/tissues]

[orgn] is used to restrict “mouse” to the organism field.

[expression/tissues] is used to restrict records to those expressed in liver only at developmental stage E14.5. Expression bins are indexed both on the full string and individual words.

From: Gene Help: Integrated Access to Genes of Genomes in the Reference Sequence Collection

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Gene Help [Internet].

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