Table 1.

The FDA Celecoxib Dosage in CYP2C9 Poor Metabolizers (2020)

PhenotypeDosage
Poor Metabolizers of CYP2C9 SubstratesIn individuals who are known or suspected to be poor CYP2C9 metabolizers (namely, CYP2C9*3/*3 or *2/*3), based on genotype or previous history/experience with other CYP2C9 substrates (such as warfarin, phenytoin) administer celecoxib starting with half the lowest recommended dose. Alternative management should be considered in juvenile rheumatoid arthritis individuals identified to be CYP2C9 poor metabolizers.

This FDA table is adapted from (1).

From: Celecoxib Therapy and CYP2C9 Genotype

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