Table 5.

Treatment of Manifestations in Individuals with Lipoid Proteinosis (LP)

Manifestation/ConcernTreatmentConsiderations/Other
Airway obstruction Microlaryngoscopic excision of laryngeal depositsImproves airway access & voice quality
TracheostomyFor significant airway obstruction
Cutaneous papules
& plaques 		Oral dimethylsulfoxide, D-penicillamine, & oral retinoid (e.g., acitretin)For skin softening & concomitant amelioration of mucosal lesions & hoarseness
Seizures ASM as determined by neurologist
  • Some persons are resistant to ASMs.
  • Successful treatment w/ASMs incl Tegretol® & Keppra® has been reported [Omrani et al 2012].

ASM = anti-seizure medication

From: Lipoid Proteinosis

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