Table 4. [Fibro-osseous Skeletal Lesions in the...]. - GeneReviews®

Skeletal Lesion	Features
Giant cell tumors of bone	Acquired lesions w/histopathologic features similar to FD, incl proliferation of bone marrow stromal cells & the presence of multiple multinucleated giant cells Typically benign, but may result in localized bone destruction & (rarely) metastases
Ossifying fibromas	Benign lesions typically affecting the mandible & maxillae & presenting w/local expansion of a firm, painless mass Ossifying fibromas are generally more aggressive than craniofacial FD lesions & are treated w/surgical excision.
Osteofibrous dysplasia	Typically occur in children age <10 yrs & most commonly affect the anterior tibia Children present w/painless localized swelling &, in rare instances, w/fracture or progressive deformity. Radiographs show a well-circumscribed radiolucent lesion w/characteristic sclerotic rim along the intracortical surface.
Cherubism	Radiographic manifestations typically incl bilateral, multilocular, radiolucent areas w/in the mandible, usually located at the angles & rami. The coronoid processes are commonly involved, whereas the condyles are rarely affected. Histologic manifestations of lesions in the mandible &/or maxilla: non-neoplastic fibrotic lesions that contain numerous multinuclear giant cells & occasionally cysts. Increase in osteoid & newly formed bone matrix is observed in the periphery.

Skeletal Lesion

Features

Giant cell tumors of bone

Acquired lesions w/histopathologic features similar to FD, incl proliferation of bone marrow stromal cells & the presence of multiple multinucleated giant cells
Typically benign, but may result in localized bone destruction & (rarely) metastases

Ossifying fibromas

Benign lesions typically affecting the mandible & maxillae & presenting w/local expansion of a firm, painless mass
Ossifying fibromas are generally more aggressive than craniofacial FD lesions & are treated w/surgical excision.

Osteofibrous dysplasia

Typically occur in children age <10 yrs & most commonly affect the anterior tibia
Children present w/painless localized swelling &, in rare instances, w/fracture or progressive deformity.
Radiographs show a well-circumscribed radiolucent lesion w/characteristic sclerotic rim along the intracortical surface.

Cherubism

Radiographic manifestations typically incl bilateral, multilocular, radiolucent areas w/in the mandible, usually located at the angles & rami. The coronoid processes are commonly involved, whereas the condyles are rarely affected.
Histologic manifestations of lesions in the mandible &/or maxilla: non-neoplastic fibrotic lesions that contain numerous multinuclear giant cells & occasionally cysts. Increase in osteoid & newly formed bone matrix is observed in the periphery.

From: Fibrous Dysplasia / McCune-Albright Syndrome

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Adam MP, Feldman J, Mirzaa GM, et al., editors.

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