Table 5.

Recommended Surveillance for Individuals with STAT3 Hyper IgE Syndrome

System/ConcernEvaluationFrequency
Skin Dermatology exam & culture of skin lesionsAs needed
Pulmonary High index of suspicion for infectionLifelong
Periodic chest imagingWith ↑ pulmonary symptoms
Sputum samplesWith ↑ pulmonary symptoms
Skeletal Scoliosis evalThrough adolescence
Dental Monitor for emergence of secondary teeth & possible need for removal of primary teethEvery 6-12 mos during childhood
Vascular
  • Brain MRA for cerebral aneurysm
  • CTA or MRA for coronary artery aneurysm
Every 3 yrs in adults
Other Monitor for lymphadenopathy, or masses due to ↑ incidence of lymphomaAnnually

From: STAT3 Hyper IgE Syndrome

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