Table 5.

Treatment of Manifestations in Individuals with SHORT Syndrome

Manifestation/ConcernTreatmentConsiderations/Other
Axenfeld-Rieger anomaly or related anterior chamber ocular anomalies Treatment by ophthalmologist experienced in management of developmental eye disorders or glaucomaImportant to ↓ & stabilize ocular pressures & to preserve vision
Hearing loss See Hereditary Hearing Loss and Deafness.
Dental anomalies Standard treatment & may incl crowns & dental prostheses.
Insulin resistance / Diabetes mellitus Standard treatment for glucose intolerance & diabetes mellitus w/diet, lifestyle, oral medication, & insulin under supervision of a specialist in diabetes care is recommended.1 report found that treatment w/metformin → worsening of insulin resistance in 1 person w/SHORT syndrome, suggesting need for caution in use of metformin & further study [Lewandowski et al 2019].

From: SHORT Syndrome

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