Table 4b.

Guidelines for Clinical Screening of Asymptomatic Family Members of a Proband in Whom the Specific Genetic Cause of HCM Has Not Been Identified

Age of Asymptomatic Relative 1Age of Onset in Affected Family Member(s)When To Initiate ScreeningRepeat EKG & 2D Echo 2
Children & adolescentsEarly onset (i.e., onset in infancy &/or childhood)At the time HCM is diagnosed in another family memberEvery 1-2 years
Onset during or after pubertyAt the time HCM is diagnosed in another family member but no later than pubertyEvery 2-3 years
AdultsAny ageAt the time HCM is diagnosed in another family memberEvery 3 to 5 years

Adapted from Ommen et al [2020]

Echo = echocardiography; EKG = electrocardiogram

1.

Includes first-degree relatives. May include more distant relatives based on clinical judgment.

2.

Screening interval may be modified based on symptom development and/or family history.

From: Hypertrophic Cardiomyopathy Overview

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