Table 7b.

Recommended Surveillance for Individuals at 50% Risk for MEN1

System/ConcernEvaluationFrequency
Parathyroid tumors
  • Fasting total serum calcium concentration (corrected for albumin) &/or ionized-serum calcium concentration
  • Fasting serum concentration of intact (full-length) PTH
Annually beginning at age 10 yrs
Anterior pituitary
adenomas 		Serum concentration of prolactinAnnually beginning at age 5 yrs
Well-differentiated
endocrine tumors of
the GEP tract
  • Fasting serum gastrin concentration
  • EUS exam
In those w/symptoms of ZES (reflux or diarrhea) annually beginning at age 20 yrs

EUS = endoscopic ultrasound; GEP = gastroenteropancreatic; PTH = parathyroid hormone; ZES = Zollinger-Ellison syndrome

From: Multiple Endocrine Neoplasia Type 1

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