Table 4. [CPIC Recommended Therapeutic Use of Allopurinol by HLA-B Genotype (2015)]. - Medical Genetics Summaries

Genotype test results	Example of diplotypes	Phenotype	Therapeutic recommendations
Negative for HLA-B58:01*	(X/X)^b	Low or reduced risk of allopurinol-induced SCAR	Use allopurinol per standard dosing guidelines
Positive for HLA-B58:01*	58:01/(X)^b 58:01/58:01	Significantly increased risk of allopurinol-induced SCAR	Allopurinol is contraindicated

From: Allopurinol Therapy and HLA-B*58:01 Genotype

Medical Genetics Summaries [Internet].

Pratt VM, Scott SA, Pirmohamed M, et al., editors.

Bethesda (MD): National Center for Biotechnology Information (US); 2012-.

All Medical Genetics Summaries content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license which permits copying, distribution, and adaptation of the work, provided the original work is properly cited and any changes from the original work are properly indicated. Any altered, transformed, or adapted form of the work may only be distributed under the same or similar license to this one.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.