Table 5. [Recommended Surveillance for Individuals with ALS2-related Disorder]. - GeneReviews®

System/Concern	Evaluation	Frequency
Neurologic involvement	Neurologic exam to monitor progression of existing findings & development of new findings	Annually or as needed
Development / Educational issues	Monitor developmental progress/educational needs.
Spine and hips	Monitor to assure early detection of scoliosis &/or hip dislocation.
Musculoskeletal/ ADL	PT & OT to monitor gross motor & fine motor skills & therapy/equipment needs
Dysarthria	Per speech & language therapist
Dysphagia	Monitor nutrition, safety of oral feeding in those w/o gastrostomy tube.
Bladder dysfunction	Per treating urologist
Bowel dysfunction	Per treating clinician
Family support/ resources	Use of local resources, coordination of care

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Adam MP, Feldman J, Mirzaa GM, et al., editors.

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