Table 5.

Alexander Disease: Comparison of Classification Systems

Classification SystemTypical Age at Presentation
First Month of LifeInfancy or ChildhoodChildhood or AdolescenceAdolescence or Adulthood
4-group system by age of onsetNeonatal formInfantile formJuvenile formAdult form
2-group system by symptoms at onset 1Type IType IType IIType II
3-group system by MRI features 2CerebralCerebralIntermediateBulbospinal
1.

Prust et al [2011] classification based on clinical findings, not age

2.

Yoshida et al [2011] classification based on brain MRI findings

From: Alexander Disease

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