Table 4. [Alexander Disease: Comparison of Forms by Select Features]. - GeneReviews®

	Neonatal	Infantile	Juvenile	Adult
Typical age at presentation	1st mo of life	Infancy or childhood	Childhood or adolescence	Adolescence or adulthood
Core neurologic manifestations	Lack of developmental progression; motor impairment w/o spasticity; seizures; megalencephaly; hydrocephalus	Developmental delay or developmental regression; seizures; megalencephaly	Bulbar/pseudobulbar signs w/nasal speech, dysphagia, dysphonia; failure to thrive; intractable vomiting; scoliosis; autonomic dysfunction	Pyramidal involvement; bulbar dysfunction; autonomic dysfunction
Other findings	Feeding difficulties (failure to thrive)	Failure to thrive	Short stature	Cerebellar involvement; palatal myoclonus; normocephaly

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