|
| Status |
Public on Jan 28, 2012 |
| Title |
Post-epidemic eosinophilia myalgia syndrome associated with L-Tryptophan |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Eosinophilia–myalgia syndrome (EMS) is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration. The EMS epidemic in 1989 was linked to L-tryptophan consumption originating from a single source. Following the Food and Drug Administration (FDA) ban on the sale of L-tryptophan, the incidence of EMS declined rapidly. Moreover, no new cases have been published since the FDA ban was lifted in 2005. We report the clinical, histopathological and immunogenetic features of a new case of L-tryptophan-associated EMS along with evidence of activated transforming growth factor-ß and interleukin-4 signaling in the lesional skin.
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| |
|
| Overall design |
6 samples were analyzed to include EMS patient and two replicates along with three normal controls
|
| |
|
| Contributor(s) |
Allen JA, Wood TA, Peterson A, Sufit R, Hinchcliff ME, Maloney JM, Miller FW, Whitfield ML, Varga J |
| Citation(s) |
21702023 |
| Submission date |
Jan 28, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Tammara Wood |
| E-mail(s) |
tammara.a.wood@dartmouth.edu
|
| Organization name |
Dartmouth Medical School
|
| Department |
Biomedical Data Science
|
| Lab |
Whitfield Lab
|
| Street address |
WTRB 674
|
| City |
Lebanon |
| State/province |
NH |
| ZIP/Postal code |
03756 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
|
| Samples (6)
|
| GSM663190 |
Left arm biopsy EMS patient replicate #2 |
| GSM663191 |
Left arm biopsy EMS patient replicate #3 |
| GSM663192 |
Left arm biopsy EMS patient |
|
| Relations |
| BioProject |
PRJNA136089 |
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