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| Status |
Public on May 18, 2024 |
| Title |
RNA sequencing of NPM1cA/SMC+/- mouse myeloid sarcoma and whole bone marrow |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
This study was designed to investigate the RNA sequencing profile of mouse myeloid sarcomas in comparison to their matched whole bone marrow acute myeloid leukemia specimens. The goal was to determine gene set profiles that are different between the two phenotypes in the same primary genetic driver of AML mutation in mice to further investigate the results demonstrated in the patient derived specimens.
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| Overall design |
Samples includes were mouse myeloid sarcomas (AML tumors) and mouse whole bone marrow specimens (infiltrated with AML). All but one pair were NPM1cA mutated in combination with heterozygous SMC3 (SMC3+/-) and one sample was NPM1cA mutated but wild type SMC3.
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| Contributor(s) |
Zorn KE, Meyer AE, Vassiliou G, Rao S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 23, 2024 |
| Last update date |
May 18, 2024 |
| Contact name |
Sridhar Rao |
| Organization name |
Versiti Blood Research Institte
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| Department |
Stem Cell Transriptional Regulation
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| Street address |
8797 Watertown Plank Rd
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| City |
Milwaukee |
| State/province |
WI |
| ZIP/Postal code |
53226 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (16)
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| GSM8226331 |
Whole Bone Marrow, Mouse 737, NPM1cA/SMC3+/-, Rep1 |
| GSM8226332 |
Whole Bone Marrow, Mouse 779, NPM1cA/SMC3+/-, Rep1 |
| GSM8226333 |
Whole Bone Marrow, Mouse 782, NPM1cA/SMC3+/-, Rep1 |
| GSM8226334 |
Myeloid Sarcoma, Mouse 841, NPM1cA, Rep1 |
| GSM8226335 |
Whole Bone Marrow, Mouse 919, NPM1cA/SMC3+/-, Rep1 |
| GSM8226336 |
Myeloid Sarcoma, Mouse 948, NPM1cA/SMC3+/-, Rep1 |
| GSM8226337 |
Myeloid Sarcoma, Mouse 948, NPM1cA/SMC3+/-, Rep2 |
| GSM8226338 |
Whole Bone Marrow, Mouse 949, NPM1cA/SMC3+/-, Rep1 |
| GSM8226339 |
Whole Bone Marrow, Mouse 1103, NPM1cA/SMC3+/-, Rep1 |
| GSM8226340 |
Whole Bone Marrow, Mouse 1267, NPM1cA/SMC3+/-, Rep1 |
| GSM8226341 |
Myeloid Sarcoma, Mouse 1267, NPM1cA/SMC3+/-, Rep1 |
| GSM8226342 |
Whole Bone Marrow, Mouse 2721, NPM1cA/SMC3+/-, Rep1 |
| GSM8226343 |
Myeloid Sarcoma, Mouse 2721, NPM1cA/SMC3+/-, Rep1 |
| GSM8226344 |
Myeloid Sarcoma, Mouse 2721, NPM1cA/SMC3+/-, Rep2 |
| GSM8226345 |
Whole Bone Marrow, Mouse 3332, NPM1cA/SMC3+/-, Rep1 |
| GSM8226346 |
Myeloid Sarcoma, Mouse 1268_1270, NPM1cA/SMC3+/-, Rep1 |
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| Relations |
| BioProject |
PRJNA1103820 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE264700_Mouse_MS_vs._Marrow_DE_Genes.xlsx |
1.9 Mb |
(ftp)(http) |
XLSX |
| GSE264700_RawCounts.csv.gz |
570.3 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
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