Table 4.2Diagnostic variables for the anorectal manometry and the rectal biopsy in children with Hirschsprung's disease

StudyTestAccuracy (%)Sensitivity (%)Specificity (%)PPV (%)NPV (%)
Jarvi 2009ARM1008380100
Biopsya100100100100100
Lee 2007ARM87.1878.7970.8391.23
Biopsy92.3110010095.65
Low 1989ARM9079979488
BiopsyUnclear but 5 children (10%) required repeat full-thickness biopsy for inadequate sampling
Kong 1993ARM901008683100
BiopsyUnclear whether or not all patients underwent rectal biopsy but it looks as this was probably the case
Penninckx 1990ARMNot possible to calculate
Biopsy

ARM: anorectal manometry

PPV: positive predictive value

NPV: negative predictive value

a

In this study operative rectal biopsy was performed, whereas suction rectal biopsy was performed in all the others

From: 4, Clinical investigations

Cover of Constipation in Children and Young People
Constipation in Children and Young People: Diagnosis and Management of Idiopathic Childhood Constipation in Primary and Secondary Care.
NICE Clinical Guidelines, No. 99.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2010.
Copyright © 2010, National Collaborating Centre for Women's and Children's Health.

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