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    eIF4E1 eukaryotic translation initiation factor 4E1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45525, updated on 10-May-2024

    Summary

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    Official Symbol
    eIF4E1provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4E1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015218
    Locus tag
    Dmel_CG4035
    See related
    AllianceGenome:FB:FBgn0015218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0260/09; 0587/11; 0589/11; 0919/12; 1004/13; 2; 7238; CBP; CG4035; CT13384; CT39424; CT39426; D-eIF4E; deIF-4E; dEif-4e; deIF4E; dEif4e; Dmel\CG4035; eIF 4E; eif-4e; eif-4E; eIF-4e; eIF-4E; eIF-4E1; eIF-4E2; eIF-4EII; eif4e; eiF4E; eIF4e; eIF4E; Eif4e; Eif4E; EIF4E; eIF4E-1; eIF4E-1/2; eIF4E-2; eIF4EI; eIF4F; elF4E; IF4E; l(3)07238; l(3)67Af; l(3)S025007; l(3)S026009; l(3)S058711; l(3)S091912
    Summary
    Enables RNA 7-methylguanosine cap binding activity; eukaryotic initiation factor 4G binding activity; and translation initiation factor activity. Involved in RNA metabolic process and translational initiation. Located in cytoplasmic ribonucleoprotein granule; cytosol; and muscle cell postsynaptic specialization. Part of eukaryotic translation initiation factor 4F complex and messenger ribonucleoprotein complex. Is expressed in several structures, including adult heart; embryonic/larval digestive system; extended germ band embryo; presumptive embryonic/larval system; and testis. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See eIF4E1 in Genome Data Viewer
    Location:
    67B4-67B4; 3-29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9399618..9402460, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9392718..9395560, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 67B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cap binding-independent recruitment of eIF4E to cytoplasmic foci. Ferrero PV, et al. Biochim Biophys Acta, 2012 Jul. PMID 22507384
    2. Localization, structure and expression of the gene for translation initiation factor eIF-4E from Drosophila melanogaster. Hernández G, et al. Mol Gen Genet, 1997 Feb 20. PMID 9065696
    3. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. Lavoie CA, et al. J Biol Chem, 1996 Jul 5. PMID 8663200
    4. Translation initiation factor eIF-4E from Drosophila: cDNA sequence and expression of the gene. Hernández G, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7742371
    5. Purification and characterization of mRNA cap-binding protein from Drosophila melanogaster embryos. Maroto FG, et al. Mol Cell Biol, 1989 May. PMID 2501660, Free PMC Article

    See all (261) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Me31B is a Dual eIF4E-Interacting Protein.
      Title: Drosophila Me31B is a Dual eIF4E-Interacting Protein.
    2. The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.
      Title: The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
    3. Phosphorylation of 4E-BP1 impairs the competition with eIF4G for eIF4E binding.
      Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.
    4. Both eIF4E-1 and eIF4E-3 are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.
      Title: Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis.
    5. eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
      Title: 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
    6. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.
      Title: Cap binding-independent recruitment of eIF4E to cytoplasmic foci.
    7. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
      Title: Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
    8. eIF4E regulates the sex-specific expression of the master switch gene Sxl.
      Title: The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.
    9. data are consistent with the idea that Parkin and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.
      Title: Diminution of eIF4E activity suppresses parkin mutant phenotypes.
    10. These results suggest that the eIF4E-1,2 gene is regulated by Hfp through a mechanism linked to transcription control and 3' splice site selection, which determines the pattern and translation efficiency of eIF4E-1,2 mRNAs.
      Title: Half pint couples transcription and splicing of eIF4E-1,2 gene during fly development.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables eukaryotic initiation factor 4G binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation at postsynapse, modulating synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation at postsynapse, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trans-synaptic signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in trans-synaptic signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in neuronal ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E1
    Names
    CG4035-PA
    CG4035-PB
    CG4035-PC
    CG4035-PD
    CG4035-PE
    CG4035-PF
    CG4035-PG
    CG4035-PH
    CG4035-PI
    cap binding protein
    eIF4E1-PA
    eIF4E1-PB
    eIF4E1-PC
    eIF4E1-PD
    eIF4E1-PE
    eIF4E1-PF
    eIF4E1-PG
    eIF4E1-PH
    eIF4E1-PI
    eukaryotic initiation factor 4E
    eukaryotic translation initiation factor 4E
    lethal(3)67Af

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9399618..9402460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168333.2 → NP_729480.1  eukaryotic translation initiation factor 4E1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48598
      Related
      FBpp0076216
      Conserved Domains (1) summary
      pfam01652
      Location:71 → 228
      IF4E; Eukaryotic initiation factor 4E

    2. NM_080090.3 → NP_524829.1  eukaryotic translation initiation factor 4E1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076215
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E

    3. NM_168335.2 → NP_729482.1  eukaryotic translation initiation factor 4E1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076217
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E

    4. NM_001274698.1 → NP_001261627.1  eukaryotic translation initiation factor 4E1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E

    5. NM_168338.2 → NP_729485.1  eukaryotic translation initiation factor 4E1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076219
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E

    6. NM_168334.1 → NP_729481.1  eukaryotic translation initiation factor 4E1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076218, FBtr0076490
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E

    7. NM_001274697.1 → NP_001261626.1  eukaryotic translation initiation factor 4E1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E

    8. NM_168336.2 → NP_729483.1  eukaryotic translation initiation factor 4E1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076220
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E

    9. NM_168337.2 → NP_729484.1  eukaryotic translation initiation factor 4E1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729484.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076221
      Conserved Domains (1) summary
      pfam01652
      Location:82 → 239
      IF4E; Eukaryotic initiation factor 4E
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    2111242A.1
    4AXG_A.1
    4AXG_B.1
    M9PBZ9 M9PBZ9
    P48598.1 P48598
    Q683T0 Q683T0
    Q683T1 Q683T1

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