Analysis of CCD-18Co colon myofibroblasts stimulated with Sonic hedgehog homolog (SHH) for 72hr. Hedgehog (Hh)-driven, CCD-18Co proangiogenic signals drive tumor angiogenesis in vitro and in vivo. Results provide insight into the molecular mechanisms underlying Hh regulation of tumor angiogenesis.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Chen W, Tang T, Eastham-Anderson J, Dunlap D et al. Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells. Proc Natl Acad Sci U S A 2011 Jun 7;108(23):9589-94. PMID: 21597001
