Analysis of glioblastoma (GBM) tumors from different regions of the brain from patients of various ages. Mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of GBM. Results provide insight into heterogeneity of GBM and oncogenic pathways leading to gliomagenesis.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Sturm D, Witt H, Hovestadt V, Khuong-Quang DA et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012 Oct 16;22(4):425-37. PMID: 23079654
