IL-10+CD8 T cell response to coronavirus infection
Summary:
Analysis of IL-10+CD8 and IL-10−CD8 T cells from C57Bl/6 Vert-X animals infected with the neurotropic coronavirus J2.2-V-1. IL-10 is a potent anti-inflammatory cytokine. Results provide insight into the role of IL-10+CD8 T cells in the immune response to coronavirus-induced encephalitis.
Trandem K, Zhao J, Fleming E, Perlman S. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol 2011 Mar 15;186(6):3642-52. PMID: 21317392
