DataSet Record GDS3478: Expression Profiles Data Analysis Tools Sample Subsets
Title: 22q11 microdeletion syndrome model: prefrontal cortex
Cluster AnalysisGDS3478 Cluster Image
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Summary: Analysis of prefrontal cortex of Df(16)A/+ animals. Df(16)A/+ animals carry microdeletions of about 1.3Mb in the locus syntenic to human 22q11.2. Individuals with 22q11.2 microdeletions show behavioral and cognitive deficits and are at high risk of developing schizophrenia.
Organism: Mus musculus
Platform: GPL1261: [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Citations:
  • Stark KL, Xu B, Bagchi A, Lai WS et al. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 2008 Jun;40(6):751-60. PMID: 18469815
  • Xu B, Hsu PK, Stark KL, Karayiorgou M et al. Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion. Cell 2013 Jan 17;152(1-2):262-75. PMID: 23332760
Reference Series: GSE10784 Sample count: 20
Value type: transformed count Series published: 2008/04/10