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Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria.
Sepuri NB, Gorla M, King MP. Sepuri NB, et al. PLoS One. 2012;7(4):e35321. doi: 10.1371/journal.pone.0035321. Epub 2012 Apr 23. PLoS One. 2012. PMID: 22539966 Free PMC article.
Aminoacyl tRNA synthetases play a central role in protein synthesis by charging tRNAs with amino acids. Yeast mitochondrial lysyl tRNA synthetase (Msk1), in addition to the aminoacylation of mitochondrial tRNA, also functions as a chaperone to facilita …
Aminoacyl tRNA synthetases play a central role in protein synthesis by charging tRNAs with amino acids. Yeast mitochondrial lysyl …
Activation of human mitochondrial lysyl-tRNA synthetase upon maturation of its premitochondrial precursor.
Dias J, Octobre G, Kobbi L, Comisso M, Flisiak S, Mirande M. Dias J, et al. Biochemistry. 2012 Jan 31;51(4):909-16. doi: 10.1021/bi201337b. Epub 2012 Jan 23. Biochemistry. 2012. PMID: 22235746
The cytoplasmic and mitochondrial species of human lysyl-tRNA synthetase are encoded by a single gene by means of alternative splicing of the KARS1 gene. ...This adaptation mechanism may prevent inhibition of translation through sequestration of lysyl- …
The cytoplasmic and mitochondrial species of human lysyl-tRNA synthetase are encoded by a single gene by means of alter …
How HIV-1 Integrase Associates with Human Mitochondrial Lysyl-tRNA Synthetase.
Phongsavanh X, Al-Qatabi N, Shaban MS, Khoder-Agha F, El Asri M, Comisso M, Guérois R, Mirande M. Phongsavanh X, et al. Viruses. 2020 Oct 21;12(10):1202. doi: 10.3390/v12101202. Viruses. 2020. PMID: 33096929 Free PMC article.
Replication of human immunodeficiency virus type 1 (HIV-1) requires the packaging of tRNA(Lys,3) from the host cell into the new viral particles. The GagPol viral polyprotein precursor associates with mitochondrial lysyl-tRNA synthetase (mLysRS) in a complex …
Replication of human immunodeficiency virus type 1 (HIV-1) requires the packaging of tRNA(Lys,3) from the host cell into the new viral parti …
Association of human mitochondrial lysyl-tRNA synthetase with HIV-1 GagPol does not require other viral proteins.
Kobbi L, Dias J, Comisso M, Mirande M. Kobbi L, et al. Biochim Open. 2016 Mar 5;2:52-61. doi: 10.1016/j.biopen.2016.02.004. eCollection 2016 Jun. Biochim Open. 2016. PMID: 29632838 Free PMC article.
In human, the cytoplasmic (cLysRS) and mitochondrial (mLysRS) species of lysyl-tRNA synthetase are encoded by a single gene. ...
In human, the cytoplasmic (cLysRS) and mitochondrial (mLysRS) species of lysyl-tRNA synthetase are encoded by a single …
Factors beyond Enolase 2 and Mitochondrial Lysyl-tRNA Synthetase Precursor Are Required for tRNA Import into Yeast Mitochondria.
Baleva MV, Meyer M, Entelis N, Tarassov I, Kamenski P, Masquida B. Baleva MV, et al. Biochemistry (Mosc). 2017 Nov;82(11):1324-1335. doi: 10.1134/S0006297917110104. Biochemistry (Mosc). 2017. PMID: 29223159
This event is believed to mask the tRNA from the cytosolic translational machinery to re-direct it towards the mitochondria. Once near the mitochondrial outer membrane, the precursor of the mitochondrial lysyl-tRNA synthetase (preMsk1p) takes ov …
This event is believed to mask the tRNA from the cytosolic translational machinery to re-direct it towards the mitochondria. Once nea …
Characterization of association of human mitochondrial lysyl-tRNA synthetase with HIV-1 Pol and tRNA(3)(Lys).
Khoder-Agha F, Dias JM, Comisso M, Mirande M. Khoder-Agha F, et al. BMC Biochem. 2018 Mar 21;19(1):2. doi: 10.1186/s12858-018-0092-x. BMC Biochem. 2018. PMID: 29562886 Free PMC article.
BACKGROUND: An important step in human immunodeficiency virus type 1 (HIV-1) replication is the packaging of tRNA(3)(Lys) from the host cell, which plays the role of primer RNA in the process of initiation of reverse transcription. The viral GagPol polyprotein precursor, and the …
BACKGROUND: An important step in human immunodeficiency virus type 1 (HIV-1) replication is the packaging of tRNA(3)(Lys) from the host cell …
Association of mitochondrial Lysyl-tRNA synthetase with HIV-1 GagPol involves catalytic domain of the synthetase and transframe and integrase domains of Pol.
Kobbi L, Octobre G, Dias J, Comisso M, Mirande M. Kobbi L, et al. J Mol Biol. 2011 Jul 29;410(5):875-86. doi: 10.1016/j.jmb.2011.03.005. J Mol Biol. 2011. PMID: 21763493 Free article.
Cytosolic and mitochondrial lysyl-tRNA synthetases (LysRS) are encoded by a single gene and can be distinguished only according to their very N-terminal sequences. ...In this work, we re-analyzed the interaction between LysRS and GagPol to determine whether t …
Cytosolic and mitochondrial lysyl-tRNA synthetases (LysRS) are encoded by a single gene and can be distinguished only a …
The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript.
Tolkunova E, Park H, Xia J, King MP, Davidson E. Tolkunova E, et al. J Biol Chem. 2000 Nov 10;275(45):35063-9. doi: 10.1074/jbc.M006265200. J Biol Chem. 2000. PMID: 10952987 Free article.
This results in a predicted protein whose carboxyl 576 amino acids are identical to those of the cytoplasmic enzyme but with a different amino terminus of 49 amino acids that contains a putative mitochondrial targeting sequence. Expression of the two lysyl-tRNA …
This results in a predicted protein whose carboxyl 576 amino acids are identical to those of the cytoplasmic enzyme but with a different ami …
Viral hijacking of mitochondrial lysyl-tRNA synthetase.
Kaminska M, Shalak V, Francin M, Mirande M. Kaminska M, et al. J Virol. 2007 Jan;81(1):68-73. doi: 10.1128/JVI.01267-06. Epub 2006 Oct 18. J Virol. 2007. PMID: 17050605 Free PMC article.
During assembly of HIV-1 particles, tRNA3(Lys) is taken up from the host cell along with lysyl-tRNA synthetase (LysRS), the tRNA binding protein that specifically aminoacylates the different tRNA(Lys) isoacceptors. In humans, the cytoplasmic and mitochondrial …
During assembly of HIV-1 particles, tRNA3(Lys) is taken up from the host cell along with lysyl-tRNA synthetase (LysRS), the tR …
Mitochondrial import of a cytoplasmic lysine-tRNA in yeast is mediated by cooperation of cytoplasmic and mitochondrial lysyl-tRNA synthetases.
Tarassov I, Entelis N, Martin RP. Tarassov I, et al. EMBO J. 1995 Jul 17;14(14):3461-71. doi: 10.1002/j.1460-2075.1995.tb07352.x. EMBO J. 1995. PMID: 7628447 Free PMC article.
Here we identify two of these factors as the cytoplasmic and mitochondrial lysyl-tRNA synthetases. The cytoplasmic enzyme is obligatory for in vitro import of the deacylated, but not of the aminoacylated tRNA. ...Its depletion leads to a total arrest of tRNA …
Here we identify two of these factors as the cytoplasmic and mitochondrial lysyl-tRNA synthetases. The cytoplasmic enzy …
44 results