No information is available on the use of asparaginase during breastfeeding. Because aspariginase is a large protein molecule with a molecular weight of about 140,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] However, the manufacturer recommends that breastfeeding be discontinued during asparaginase therapy and for 1 week after the final dose.