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The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).
Oncogene. 2002 Sep 5;21(39):6123-31. doi: 10.1038/sj.onc.1205842.
Oncogene. 2002.
PMID: 12203124
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.
Perez-Sanchez C, Budhram-Mahadeo VS, Latchman DS.
Perez-Sanchez C, et al.
Nucleic Acids Res. 2002 Nov 15;30(22):4872-80. doi: 10.1093/nar/gkf610.
Nucleic Acids Res. 2002.
PMID: 12433990
Free PMC article.
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