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HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms.
Arch Biochem Biophys. 2000 Jan 15;373(2):361-7. doi: 10.1006/abbi.1999.1583.
Arch Biochem Biophys. 2000.
PMID: 10620360
The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR.
Brand SR, Kobayashi R, Mathews MB.
Brand SR, et al.
J Biol Chem. 1997 Mar 28;272(13):8388-95. doi: 10.1074/jbc.272.13.8388.
J Biol Chem. 1997.
PMID: 9079663
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