RecName: Full=Mediator of RNA polymerase II transcription subunit 27; - Protein

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

Biallelic MED27 variants lead to variable ponto-cerebello-lental degeneration with movement disorders. [Brain. 2023]
Biallelic MED27 variants lead to variable ponto-cerebello-lental degeneration with movement disorders.
Maroofian R, Kaiyrzhanov R, Cali E, Zamani M, Zaki MS, Ferla M, Tortora D, Sadeghian S, Saadi SM, Abdullah U, et al. Brain. 2023 Dec 1; 146(12):5031-5043.
Knockdown of mediator complex subunit 27 suppresses gastric cancer cell metastasis and angiogenesis via Wnt/β-catenin pathway. [Tissue Cell. 2022]
Knockdown of mediator complex subunit 27 suppresses gastric cancer cell metastasis and angiogenesis via Wnt/β-catenin pathway.
Han X, Liu H, Tang X, Zhao Y. Tissue Cell. 2022 Dec; 79:101973. Epub 2022 Nov 9.
MED27 Variants Cause Developmental Delay, Dystonia, and Cerebellar Hypoplasia. [Ann Neurol. 2021]
MED27 Variants Cause Developmental Delay, Dystonia, and Cerebellar Hypoplasia.
Meng L, Isohanni P, Shao Y, Graham BH, Hickey SE, Brooks S, Suomalainen A, Joset P, Steindl K, Rauch A, et al. Ann Neurol. 2021 Apr; 89(4):828-833. Epub 2021 Feb 8.

RefSeq protein isoforms
See 9 reference sequence protein isoforms for the MED27 gene.

PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Identical Structures
3D structures for identical protein sequences
OMIM
OMIM records associated with protein sequence
Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq)
PubMed (Weighted)
Links to pubmed

Q6P2C8 [Domain Mapping of Disease Mut...]
Q6P2C8
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

RecName: Full=Mediator of RNA polymerase II transcription subunit 27; AltName: F...
RecName: Full=Mediator of RNA polymerase II transcription subunit 27; AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 8; Short=CRSP complex subunit 8; AltName: Full=Mediator complex subunit 27; AltName: Full=P37 TRAP/SMCC/PC2 subunit; AltName: Full=Transcriptional coactivator CRSP34
gi|74737195|sp|Q6P2C8.1|MED27_HUMAN

Protein

Your browsing activity is empty.

Activity recording is turned off.

Protein