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Select item 110684121.

Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life

Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Shana Kahnamoui, Bo Xiang, Andrew J. Halayko, Vernon W. Dolinsky, Christopher D. Pascoe, Meaghan J. Jones

Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1; 325(5): L552–L567. Published online 2023 Aug 29. doi: 10.1152/ajplung.00192.2023

PMCID:: PMC11068412

Abstract Article

Select item 101746182.

Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice

Karolína Ondrová, Iveta Zůvalová, Barbora Vyhlídalová, Kristýna Krasulová, Eva Miková, Radim Vrzal, Petr Nádvorník, Binod Nepal, Sandhya Kortagere, Martina Kopečná, David Kopečný, Marek Šebela, Fraydoon Rastinejad, Hua Pu, Miroslav Soural, Katharina Maria Rolfes, Thomas Haarmann-Stemmann, Hao Li, Sridhar Mani, Zdeněk Dvořák

Nat Commun. 2023; 14: 2728. Published online 2023 May 11. doi: 10.1038/s41467-023-38478-6

PMCID:: PMC10174618

Abstract Article PDF–3.4M

Select item 94934743.

Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis

Sweta Ghosh, Bhagavatula Moorthy, Bodduluri Haribabu, Venkatakrishna Rao Jala

Front Immunol. 2022; 13: 1004603. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.1004603

PMCID:: PMC9493474

Abstract Article PDF–18M

Select item 92072684.

Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation

Francesca Alessandrini, Renske de Jong, Maria Wimmer, Ann-Marie Maier, Isis Fernandez, Miriam Hils, Jeroen T. Buters, Tilo Biedermann, Ulrich M. Zissler, Christian Hoffmann, Julia Esser-von-Bieren, Carsten B. Schmidt-Weber, Caspar Ohnmacht

Front Immunol. 2022; 13: 901194. Published online 2022 Jun 6. doi: 10.3389/fimmu.2022.901194

PMCID:: PMC9207268

Abstract Article PDF–6.0M

Select item 87286915.

Molecular Mechanisms of Pulmonary Carcinogenesis by Polycyclic Aromatic Hydrocarbons (PAHs): Implications for Human Lung Cancer

Rachel Stading, Grady Gastelum, Chun Chu, Weiwu Jiang, Bhagavatula Moorthy

Semin Cancer Biol. Author manuscript; available in PMC 2022 Jan 5.

Published in final edited form as: Semin Cancer Biol. 2021 Nov; 76: 3–16. Published online 2021 Jul 7. doi: 10.1016/j.semcancer.2021.07.001

PMCID:: PMC8728691

Abstract Article PDF–1.9M

Select item 85790416.

Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells

Rahwa Taddese, Rian Roelofs, Derk Draper, Xinqun Wu, Shaoguang Wu, Dorine W. Swinkels, Harold Tjalsma, Annemarie Boleij

Front Cell Infect Microbiol. 2021; 11: 740704. Published online 2021 Oct 27. doi: 10.3389/fcimb.2021.740704

PMCID:: PMC8579041

Abstract Article PDF–1.7M

Select item 81529177.

CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway

Mariela Kyoreva, Ying Li, Mariyah Hoosenally, Jonathan Hardman-Smart, Kirsten Morrison, Isabella Tosi, Mauro Tolaini, Guillermo Barinaga, Brigitta Stockinger, Ulrich Mrowietz, Frank O. Nestle, Catherine H. Smith, Jonathan N. Barker, Paola Di Meglio

J Invest Dermatol. 2021 Jun; 141(6): 1553–1563.e3. doi: 10.1016/j.jid.2020.11.024

PMCID:: PMC8152917

Abstract Article

Select item 78188998.

Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2

Grady Gastelum, Weiwu Jiang, Lihua Wang, Guodong Zhou, Roshan Borkar, Nagireddy Putluri, Bhagavatula Moorthy

Toxicol Sci. 2020 Oct; 177(2): 347–361. Published online 2020 Jul 29. doi: 10.1093/toxsci/kfaa107

PMCID:: PMC7818899

Abstract Article PDF–1.4M

Select item 76097879.

Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation

Li‐xing Tian, Xin Tang, Wei Ma, Jing Wang, Wei Zhang, Kuan Liu, Tao Chen, Jun‐yu Zhu, Hua‐ping Liang

FEBS Open Bio. 2020 Nov; 10(11): 2316–2328. Published online 2020 Sep 23. doi: 10.1002/2211-5463.12977

PMCID:: PMC7609787

Abstract Article PDF–6.8M

Select item 746731610.

Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity

Zhengzheng S. Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E. Vancollie, Ximena Ibarra-Soria, Helen V. Firth, Debra Rimmington, I. Sadaf Farooqi, Christopher J. Lelliott, Steven C. Munger, Stephen O’Rahilly, Anne C. Ferguson-Smith, Anthony P. Coll, Darren W. Logan

PLoS Genet. 2020 Sep; 16(9): e1008916. Published online 2020 Sep 2. doi: 10.1371/journal.pgen.1008916

PMCID:: PMC7467316

Abstract Article PDF–3.4M

Select item 733580511.

Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity

Naoko Nakano, Nobuo Sakata, Yuki Katsu, Daiki Nochise, Erika Sato, Yuta Takahashi, Saori Yamaguchi, Yoko Haga, Souichi Ikeno, Mitsuyoshi Motizuki, Keigo Sano, Kohei Yamasaki, Keiji Miyazawa, Susumu Itoh

J Biol Chem. 2020 Jul 3; 295(27): 9033–9051. Published online 2020 May 14. doi: 10.1074/jbc.RA120.013596

PMCID:: PMC7335805

Abstract Article PDF–4.4M

Select item 694913312.

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

Colin J. Henderson, Lesley A. McLaughlin, Maria Osuna-Cabello, Malcolm Taylor, Ian Gilbert, Aileen W. McLaren, C. Roland Wolf

Biochem J. Author manuscript; available in PMC 2020 Jan 8.

Published in final edited form as: Biochem J. 2015 Feb 1; 465(3): 479–488. doi: 10.1042/BJ20140582

PMCID:: PMC6949133

Abstract Article PDF–1.5M

Select item 665721613.

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode, C. R. Wolf

Drug Metab Dispos. 2019 Aug; 47(8): 907–918. Published online 2019 Jul 19. doi: 10.1124/dmd.119.087718

PMCID:: PMC6657216

Abstract Article PDF–1.4M

Select item 660240714.

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma

Abigail G Zieman, Brian G Poll, Jingqun Ma, Pierre A Coulombe

Hum Mol Genet. 2019 Jul 1; 28(13): 2255–2270. Published online 2019 Mar 20. doi: 10.1093/hmg/ddz050

PMCID:: PMC6602407

Abstract Article PDF–3.5M

Select item 650538015.

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

C.J. Henderson, Y. Kapelyukh, N. Scheer, A. Rode, AW. McLaren, A.K. MacLeod, D. Lin, J. Wright, L.A. Stanley, C.R. Wolf

Drug Metab Dispos. 2019 Jun; 47(6): 601–615. Published online 2019 Jun. doi: 10.1124/dmd.119.086397

PMCID:: PMC6505380

Abstract Article PDF–1.7M

Select item 591955316.

Aberrant CYP1A1 Induction: Discrepancy of CYP1A1 mRNA and Aryl Hydrocarbon Hydroxylase Activity in Mutant Cells of Mouse Hepatoma Line, Hepa‐1

Hideaki Kikuchi, Masahiro Usuda, Ikuko Sagami, Shuntaro Ikawa, Minro Watanabe

Jpn J Cancer Res. 1994 Jul; 85(7): 710–717. doi: 10.1111/j.1349-7006.1994.tb02419.x

PMCID:: PMC5919553

Summary PDF–493K

Select item 591867317.

Species Difference among Experimental Rodents in Induction of P450IA Family Enzymes by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

Masakuni Degawa, Ken‐ichiro Kobayashi, Shin‐ichi Miura, Hiroshi Arai, Hiroyasu Esumi, Takashi Sugimura, Yoshiyuki Hashimoto

Jpn J Cancer Res. 1992 Oct; 83(10): 1047–1051. doi: 10.1111/j.1349-7006.1992.tb02720.x

PMCID:: PMC5918673

Summary PDF–504K

Select item 590415918.

Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR

Christopher Manzella, Megha Singhal, Waddah A. Alrefai, Seema Saksena, Pradeep K. Dudeja, Ravinder K. Gill

Sci Rep. 2018; 8: 6103. Published online 2018 Apr 17. doi: 10.1038/s41598-018-24213-5

PMCID:: PMC5904159

Abstract Article PDF–3.0M

Select item 583745419.

Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants

Paramahamsa Maturu, Yanhong Wei-Liang, Weiwu Jiang, Lihua Wang, Krithika Lingappan, Roberto Barrios, Yao Liang, Bhagavatula Moorthy, Xanthi I. Couroucli

Toxicol Sci. 2017 May; 157(1): 260–271. Published online 2017 Feb 13. doi: 10.1093/toxsci/kfx036