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Select item 99814401.

Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer

Jiaying Li, Li Li, Gulijiang Mahesutihan, Juanjuan Meng, Yuan Chen, Jingsen Lv

Medicine (Baltimore) 2023 Mar 3; 102(9): e32972. Published online 2023 Mar 3. doi: 10.1097/MD.0000000000032972

PMCID:: PMC9981440

Abstract Article PDF–1.4M

Select item 88735662.

Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia

Dipabarna Bhattacharya, Antonella Teramo, Vanessa Rebecca Gasparini, Jani Huuhtanen, Daehong Kim, Jason Theodoropoulos, Gianluca Schiavoni, Gregorio Barilà, Cristina Vicenzetto, Giulia Calabretto, Monica Facco, Toru Kawakami, Hideyuki Nakazawa, Brunangelo Falini, Enrico Tiacci, Fumihiro Ishida, Gianpietro Semenzato, Tiina Kelkka, Renato Zambello, Satu Mustjoki

Blood Cancer J. 2022 Feb; 12(2): 31. Published online 2022 Feb 24. doi: 10.1038/s41408-022-00630-8

PMCID:: PMC8873566

Abstract Article PDF–2.4M

Select item 78549923.

Developmental adaptive immune defects associated with STAT5B deficiency in three young siblings

Corinne L. Foley, Sareea S. Al Remeithi, Christopher T. Towe, Andrew Dauber, Philippe F Backeljauw, Leah Tyzinski, Ashish R. Kumar, Vivian Hwa

J Clin Immunol. Author manuscript; available in PMC 2021 Feb 3.

Published in final edited form as: J Clin Immunol. 2021 Jan; 41(1): 136–146. Published online 2020 Oct 22. doi: 10.1007/s10875-020-00884-6

PMCID:: PMC7854992

Abstract Article PDF–1.0M

Select item 77019804.

Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas

A Nicolae, L Xi, S Pittaluga, Z Abdullaev, SD Pack, J Chen, TA Waldmann, ES Jaffe, M Raffeld

Leukemia. Author manuscript; available in PMC 2020 Nov 30.

Published in final edited form as: Leukemia. 2014 Nov; 28(11): 2244–2248. Published online 2014 Jun 20. doi: 10.1038/leu.2014.200

PMCID:: PMC7701980

Article PDF–1.3M

Select item 71553805.

Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function.

Alexander Vargas-Hernández, Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, Klara Klein, Sanjana Mahapatra, Waleed Al-Herz, Emily M. Mace, Alexandre F. Carisey, Jordan S Orange, Veronika Sexl, Lisa R. Forbes

J Allergy Clin Immunol. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Allergy Clin Immunol. 2020 Jan; 145(1): 345–357.e9. Published online 2019 Oct 7. doi: 10.1016/j.jaci.2019.09.016

PMCID:: PMC7155380

Abstract Article PDF–2.0M

Select item 64742966.

The Signal Transducer and Activator of Transcription 5B (STAT5B) Gene Promotes Proliferation and Drug Resistance of Human Mantle Cell Lymphoma Cells by Activating the Akt Signaling Pathway

Wenjun Zhang, Xiping Liang, Yi Gong, Chunyan Xiao, Bingling Guo, Tao Yang

Med Sci Monit. 2019; 25: 2599–2608. Published online 2019 Apr 9. doi: 10.12659/MSM.914934

PMCID:: PMC6474296

Abstract Article PDF–1.9M

Select item 63654907.

Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia

Nicholas C. P. Cross, Yvette Hoade, William J. Tapper, Gonzalo Carreno-Tarragona, Tiziana Fanelli, Mohamad Jawhar, Nicole Naumann, Iwo Pieniak, Johannes Lübke, Sahra Ali, Kaljit Bhuller, Sonja Burgstaller, Catherine Cargo, Jamie Cavenagh, Andrew S. Duncombe, Emma Das-Gupta, Paul Evans, Peter Forsyth, Philip George, Charlotte Grimley, Fergus Jack, Laura Munro, Varun Mehra, Kavita Patel, Ali Rismani, Gabriela Sciuccati, Rowena Thomas-Dewing, Patrick Thornton, Andres Virchis, Simon Watt, Louise Wallis, Alastair Whiteway, Kris Zegocki, Barbara J. Bain, Andreas Reiter, Andrew Chase

Leukemia. 2019; 33(2): 415–425. Published online 2018 Dec 20. doi: 10.1038/s41375-018-0342-3

PMCID:: PMC6365490

Abstract Article PDF–1.5M

Select item 63202598.

Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain

Meghan J. Acres, Florian Gothe, Angela Grainger, Andrew J. Skelton, David J. Swan, Joseph D.P. Willet, Suzy Leech, Sonya Galcheva, Violeta Iotova, Sophie Hambleton, Karin R. Engelhardt

J Allergy Clin Immunol. 2019 Jan; 143(1): 413–416.e4. doi: 10.1016/j.jaci.2018.08.032

PMCID:: PMC6320259

Article PDF–1.6M

Select item 59740249.

Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation

Jürgen Klammt, David Neumann, Evelien F. Gevers, Shayne F. Andrew, I. David Schwartz, Denise Rockstroh, Roberto Colombo, Marco A. Sanchez, Doris Vokurkova, Julia Kowalczyk, Louise A. Metherell, Ron G. Rosenfeld, Roland Pfäffle, Mehul T. Dattani, Andrew Dauber, Vivian Hwa

Nat Commun. 2018; 9: 2105. Published online 2018 May 29. doi: 10.1038/s41467-018-04521-0

PMCID:: PMC5974024

Abstract Article PDF–1.6M

Select item 529098910.

Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea

Chi A. Ma, Liqiang Xi, Brian Cauff, Adam DeZure, Alexandra F. Freeman, Sophie Hambleton, Gary Kleiner, T. Ronan Leahy, Maureen O’Sullivan, Michelle Makiya, Grainne O’Regan, Stefania Pittaluga, Julie Niemela, Jennifer Stoddard, Sergio D. Rosenzweig, Mark Raffeld, Amy D. Klion, Joshua D. Milner

Blood. 2017 Feb 2; 129(5): 650–653. doi: 10.1182/blood-2016-09-737817

PMCID:: PMC5290989

Article

Select item 511449011.

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia

Emma I. Andersson, Takahiro Tanahashi, Nodoka Sekiguchi, Vanessa Rebecca Gasparini, Sabrina Bortoluzzi, Toru Kawakami, Kazuyuki Matsuda, Takeki Mitsui, Samuli Eldfors, Stefania Bortoluzzi, Alessandro Coppe, Andrea Binatti, Sonja Lagström, Pekka Ellonen, Noriyasu Fukushima, Sayaka Nishina, Noriko Senoo, Hitoshi Sakai, Hideyuki Nakazawa, Yok-Lam Kwong, Thomas P. Loughran, Jaroslaw P. Maciejewski, Satu Mustjoki, Fumihiro Ishida

Blood. 2016 Nov 17; 128(20): 2465–2468. doi: 10.1182/blood-2016-06-724856

PMCID:: PMC5114490

Article

Select item 489876112.

STAT5B mutations in heterozygous state have negative impact on height: another clue in human stature heritability

Renata C Scalco, Vivian Hwa, Horacio M. Domené, Héctor G. Jasper, Alicia Belgorosky, Roxana Marino, Alberto M. Pereira, Carlos A. Tonelli, Jan M. Wit, Ron G. Rosenfeld, Alexander A.L. Jorge

Eur J Endocrinol. Author manuscript; available in PMC 2016 Jun 8.

Published in final edited form as: Eur J Endocrinol. 2015 Sep; 173(3): 291–296. Published online 2015 Jun 1. doi: 10.1530/EJE-15-0398

PMCID:: PMC4898761

Abstract Article PDF–148K

Select item 486994013.

Suppression of STAT5b in pancreatic cancer cells leads to attenuated gemcitabine chemoresistance, adhesion and invasion

HIROKI SUMIYOSHI, AKIRA MATSUSHITA, YOSHIHARU NAKAMURA, YOKO MATSUDA, TOSHIYUKI ISHIWATA, ZENYA NAITO, EIJI UCHIDA

Oncol Rep. 2016 Jun; 35(6): 3216–3226. Published online 2016 Apr 1. doi: 10.3892/or.2016.4727

PMCID:: PMC4869940

Abstract Article PDF–803K

Select item 418126714.

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

Obul R. Bandapalli, Stephanie Schuessele, Joachim B. Kunz, Tobias Rausch, Adrian M. Stütz, Noa Tal, Ifat Geron, Nava Gershman, Shai Izraeli, Juliane Eilers, Nina Vaezipour, Renate Kirschner-Schwabe, Jana Hof, Arend von Stackelberg, Martin Schrappe, Martin Stanulla, Martin Zimmermann, Rolf Koehler, Smadar Avigad, Rupert Handgretinger, Viktoras Frismantas, Jean Pierre Bourquin, Beat Bornhauser, Jan O. Korbel, Martina U. Muckenthaler, Andreas E. Kulozik

Haematologica. 2014 Oct; 99(10): e188–e192. doi: 10.3324/haematol.2014.104992

PMCID:: PMC4181267

Article PDF–265K

Select item 366848715.

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

Hanna L. M. Rajala, Samuli Eldfors, Heikki Kuusanmäki, Arjan J. van Adrichem, Thomas Olson, Sonja Lagström, Emma I. Andersson, Andres Jerez, Michael J. Clemente, Yiyi Yan, Dan Zhang, Andy Awwad, Pekka Ellonen, Olli Kallioniemi, Krister Wennerberg, Kimmo Porkka, Jaroslaw P. Maciejewski, Thomas P. Loughran, Jr, Caroline Heckman, Satu Mustjoki

Blood. 2013 May 30; 121(22): 4541–4550. Prepublished online 2013 Apr 17. doi: 10.1182/blood-2012-12-474577

PMCID:: PMC3668487

Abstract Article

Select item 354521916.

Severe Growth Deficiency is Associated with STAT5b Mutations that Disrupt Protein Folding and Activity

Benjamin Varco-Merth, Eva Feigerlová, Ujwal Shinde, Ron G. Rosenfeld, Vivian Hwa, Peter Rotwein

Mol Endocrinol. 2013 Jan; 27(1): 150–161. Published online 2012 Nov 16. doi: 10.1210/me.2012-1275

PMCID:: PMC3545219

Abstract Article

Select item 349815417.

The Jak/Stat Signaling Pathway Is Downregulated at Febrile Temperatures

Tobias Nespital, Ger J. Strous

PLoS One. 2012; 7(11): e49374. Published online 2012 Nov 14. doi: 10.1371/journal.pone.0049374

PMCID:: PMC3498154

Abstract Article PDF–337K

Select item 347983718.

STAT5b as Molecular Target in Pancreatic Cancer—Inhibition of Tumor Growth, Angiogenesis, and Metastases

Christian Moser, Petra Ruemmele, Sebastian Gehmert, Hedwig Schenk, Marina P Kreutz, Maria E Mycielska, Christina Hackl, Alexander Kroemer, Andreas A Schnitzbauer, Oliver Stoeltzing, Hans J Schlitt, Edward K Geissler, Sven A Lang

Neoplasia. 2012 Oct; 14(10): 915–925. doi: 10.1593/neo.12878

PMCID:: PMC3479837

Abstract Article PDF–1.1M

Select item 342289419.

Constitutive Activation of STAT5 Contributes to Tumor Growth, Epithelial-Mesenchymal Transition, and Resistance to EGFR Targeting

Priya Koppikar, Vivian Wai Yan Lui, David Man, Sichuan Xi, Raymond Liu Chai, Elizabeth Nelson, Allison BJ Tobey, Jennifer Rubin Grandis

Clin Cancer Res. Author manuscript; available in PMC 2012 Aug 20.

Published in final edited form as: Clin Cancer Res. 2008 Dec 1; 14(23): 7682–7690. doi: 10.1158/1078-0432.CCR-08-1328

PMCID:: PMC3422894

Abstract Article PDF–1.7M

Select item 335132820.

Signal Transducer and Activator of Transcription 5b (Stat5b) Serine 193 Is a Novel Cytokine-induced Phospho-regulatory Site That Is Constitutively Activated in Primary Hematopoietic Malignancies

Abhisek Mitra, Jeremy A. Ross, Georgialina Rodriguez, Zsuzsanna S. Nagy, Harry L. Wilson, Robert A. Kirken

J Biol Chem. 2012 May 11; 287(20): 16596–16608. Published online 2012 Mar 22. doi: 10.1074/jbc.M111.319756

PMCID:: PMC3351328

Abstract Article PDF–3.8M

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