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Select item 101368381.

IKKβ Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium

Srinivasa R. Sripathi, Ming-Wen Hu, Ravi Chakra Turaga, Rebekah Mikeasky, Ganesh Satyanarayana, Jie Cheng, Yukan Duan, Julien Maruotti, Karl J. Wahlin, Cynthia A. Berlinicke, Jiang Qian, Noriko Esumi, Donald J. Zack

Cells. 2023 Apr; 12(8): 1155. Published online 2023 Apr 13. doi: 10.3390/cells12081155

PMCID:: PMC10136838

Abstract Article PDF–5.7M

Select item 91200282.

NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes

Peng Xiao, Tatiana Takiishi, Natalia Moretti Violato, Giada Licata, Francesco Dotta, Guido Sebastiani, Lorella Marselli, Sumeet Pal Singh, Mozes Sze, Geert Van Loo, Emmanuel Dejardin, Esteban Nicolas Gurzov, Alessandra Kupper Cardozo

Cell Death Dis. 2022 May; 13(5): 476. Published online 2022 May 19. doi: 10.1038/s41419-022-04931-5

PMCID:: PMC9120028

Abstract Article PDF–3.6M

Select item 87439623.

Clinicopathological analysis and prognostic significance of NF-κB p65 and IKKβ protein and mRNA expression in nasopharyngeal carcinoma

Mei Zhou, Gang Zhao, Xiaojun Zhou, Ruixia Xuan, Yuwei Chen, Yun Wang

J Int Med Res. 2022 Jan; 50(1): 03000605211069195. Published online 2022 Jan 7. doi: 10.1177/03000605211069195

PMCID:: PMC8743962

Abstract Article PDF–630K

Select item 83202074.

Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling

Yingru Xu, Shuxia Zhang, Xinyi Liao, Man Li, Suwen Chen, Xincheng Li, Xingui Wu, Meisongzhu Yang, Miaoling Tang, Yameng Hu, Ziwen Li, Ruyuan Yu, Mudan Huang, Libing Song, Jun Li

Mol Cancer. 2021; 20: 98. Published online 2021 Jul 29. doi: 10.1186/s12943-021-01394-8

PMCID:: PMC8320207

Abstract Article PDF–17M

Select item 81766545.

Heterozygous IKKβ Activation Loop Mutation Results in a Complex Immunodeficiency Syndrome

Jordan Abbott, Angelica C Ehler, Divya Jayaraman, Paul R Reynolds, Kanao Otsu, Laurie Manka, Erwin W Gelfand

J Allergy Clin Immunol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: J Allergy Clin Immunol. 2021 Feb; 147(2): 737–740.e6. Published online 2020 Jun 15. doi: 10.1016/j.jaci.2020.06.007

PMCID:: PMC8176654

Abstract Article PDF–839K

Select item 62933396.

The IκB kinase complex is a regulator of mRNA stability

Nadine Mikuda, Marina Kolesnichenko, Patrick Beaudette, Oliver Popp, Bora Uyar, Wei Sun, Ahmet Bugra Tufan, Björn Perder, Altuna Akalin, Wei Chen, Philipp Mertins, Gunnar Dittmar, Michael Hinz, Claus Scheidereit

EMBO J. 2018 Dec 14; 37(24): e98658. Published online 2018 Nov 22. doi: 10.15252/embj.201798658

PMCID:: PMC6293339

Abstract Article PDF–2.8M

Select item 61307237.

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach

Karpagam Veerappan, Sathishkumar Natarajan, Purushoth Ethiraj, Umashankar Vetrivel, Shila Samuel

Pharm Biol. 2017; 55(1): 368–373. Published online 2016 Dec 8. doi: 10.1080/13880209.2016.1241809

PMCID:: PMC6130723

Abstract Article PDF–811K

Select item 60289658.

Mechanism of vaccinia viral protein B14–mediated inhibition of IκB kinase β activation

Qingyu Tang, Sayan Chakraborty, Guozhou Xu

J Biol Chem. 2018 Jun 29; 293(26): 10344–10352. Published online 2018 May 10. doi: 10.1074/jbc.RA118.002817

PMCID:: PMC6028965

Abstract Article PDF–2.2M

Select item 60004449.

IKBKB在人肺腺癌细胞株A549及其耐药细胞株A549/DDP中的表达和意义

齐康, 李洋, 李雪冰, 张芳, 邵宜, 周清华

Zhongguo Fei Ai Za Zhi. 2014 May 20; 17(5): 363–368. Chinese. doi: 10.3779/j.issn.1009-3419.2014.05.01

PMCID:: PMC6000444

Abstract Article PDF–1.1M

Select item 536242010.

IκB-Kinase-epsilon (IKKε) over-expression promotes the growth of prostate cancer through the C/EBP-β dependent activation of IL-6 gene expression

Benjamin Péant, Sophie Gilbert, Cécile Le Page, Alexis Poisson, Emilie L’Ecuyer, Zied Boudhraa, Marc Nicolas Bienz, Nathalie Delvoye, Fred Saad, Anne-Marie Mes-Masson

Oncotarget. 2017 Feb 28; 8(9): 14487–14501. Published online 2016 Aug 26. doi: 10.18632/oncotarget.11629

PMCID:: PMC5362420

Abstract Article PDF–6.6M

Select item 524728811.

Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition

Anfernee Kai-Wing Tse, Ying-Jie Chen, Xiu-Qiong Fu, Tao Su, Ting Li, Hui Guo, Pei-Li Zhu, Hiu-Yee Kwan, Brian Chi-Yan Cheng, Hui-Hui Cao, Sally Kin-Wah Lee, Wang-Fun Fong, Zhi-Ling Yu

Redox Biol. 2017 Apr; 11: 562–576. Published online 2017 Jan 12. doi: 10.1016/j.redox.2017.01.010

PMCID:: PMC5247288

Abstract Article PDF–2.2M

Select item 502468212.

IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3

Michael A. Reid, Xazmin H. Lowman, Min Pan, Thai Q. Tran, Marc O. Warmoes, Mari B. Ishak Gabra, Ying Yang, Jason W. Locasale, Mei Kong

Genes Dev. 2016 Aug 15; 30(16): 1837–1851. doi: 10.1101/gad.287235.116

PMCID:: PMC5024682

Abstract Article PDF–1.6M

Select item 474175013.

Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

Jakub Mieczkowski, Marta Kocyk, Pawel Nauman, Konrad Gabrusiewicz, Małgorzata Sielska, Piotr Przanowski, Marta Maleszewska, Wenson D. Rajan, Dominika Pszczolkowska, Tomasz Tykocki, Wieslawa Grajkowska, Katarzyna Kotulska, Marcin Roszkowski, Boguslaw Kostkiewicz, Bozena Kaminska

Oncotarget. 2015 Oct 20; 6(32): 33077–33090. Published online 2015 Sep 29. doi: 10.18632/oncotarget.5310

PMCID:: PMC4741750

Abstract Article PDF–4.9M

Select item 469490614.

IKK inhibition increases bortezomib effectiveness in ovarian cancer

Bipradeb Singha, Himavanth Reddy Gatla, Sai Phyo, Atish Patel, Zhe-Sheng Chen, Ivana Vancurova

Oncotarget. 2015 Sep 22; 6(28): 26347–26358. Published online 2015 Jul 20. doi: 10.18632/oncotarget.4713

PMCID:: PMC4694906

Abstract Article PDF–3.6M

Select item 461500315.

Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signaling

Leandro H Gallo, April N Meyer, Khatereh Motamedchaboki, Katelyn N Nelson, Martin Haas, Daniel J Donoghue

Cell Cycle. 2014 Dec 15; 13(24): 3964–3976. Published online 2014 Dec 8. doi: 10.4161/15384101.2014.988026

PMCID:: PMC4615003

Abstract Article PDF–1.3M

Select item 426036216.

A nonsense mutation in IKBKB causes combined immunodeficiency

Talal Mousallem, Jialong Yang, Thomas J. Urban, Hongxia Wang, Mehdi Adeli, Roberta E. Parrott, Joseph L. Roberts, David B. Goldstein, Rebecca H. Buckley, Xiao-Ping Zhong

Blood. 2014 Sep 25; 124(13): 2046–2050. Prepublished online 2014 Aug 18. doi: 10.1182/blood-2014-04-571265

PMCID:: PMC4260362

Abstract Article

Select item 417533617.

IκB Kinase β (IKBKB) Mutations in Lymphomas That Constitutively Activate Canonical Nuclear Factor κB (NFκB) Signaling

Xin Kai, Vasant Chellappa, Carlos Donado, Deepak Reyon, Yurie Sekigami, Dalya Ataca, Abner Louissaint, Hamid Mattoo, J. Keith Joung, Shiv Pillai

J Biol Chem. 2014 Sep 26; 289(39): 26960–26972. Published online 2014 Aug 8. doi: 10.1074/jbc.M114.598763

PMCID:: PMC4175336

Abstract Article PDF–3.2M

Select item 410854118.

IKKβ Activity Drives Fetal Lung Macrophage Maturation Along a Non-M1/M2 Paradigm

Ashley N. Stouch, Rinat Zaynagetdinov, Whitney J. Barham, Amanda M. Stinnett, James C. Slaughter, Fiona E. Yull, Hal M. Hoffman, Timothy S. Blackwell, Lawrence S. Prince

J Immunol. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: J Immunol. 2014 Aug 1; 193(3): 1184–1193. Published online 2014 Jun 30. doi: 10.4049/jimmunol.1302516