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Select item 72997001.

The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells

Abdennour Douida, Frank Batista, Agnieszka Robaszkiewicz, Pal Boto, Azzam Aladdin, Mónika Szenykiv, Rita Czinege, László Virág, Krisztina Tar

J Cell Mol Med. 2020 Jun; 24(12): 6716–6730. Published online 2020 May 5. doi: 10.1111/jcmm.15323

PMCID:: PMC7299700

Abstract Article PDF–995K

Select item 68633902.

Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

Ana Toste Rêgo, Paula C.A. da Fonseca

Mol Cell. 2019 Oct 3; 76(1): 138–147.e5. doi: 10.1016/j.molcel.2019.07.014

PMCID:: PMC6863390

Abstract Article

Select item 61724573.

DNA damage‐induced replication stress results in PA200‐proteasome‐mediated degradation of acetylated histones

Imke K Mandemaker, Marit E Geijer, Iris Kik, Karel Bezstarosti, Erikjan Rijkers, Anja Raams, Roel C Janssens, Hannes Lans, Jan HJ Hoeijmakers, Jeroen AA Demmers, Wim Vermeulen, Jurgen A Marteijn

EMBO Rep. 2018 Oct; 19(10): e45566. Published online 2018 Aug 13. doi: 10.15252/embr.201745566

PMCID:: PMC6172457

Abstract Article PDF–1.1M

Select item 79145024.

Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing

Abdennour Douida, Frank Batista, Pal Boto, Zsolt Regdon, Agnieszka Robaszkiewicz, Krisztina Tar

Int J Mol Sci. 2021 Feb; 22(4): 1629. Published online 2021 Feb 5. doi: 10.3390/ijms22041629

PMCID:: PMC7914502

Abstract Article PDF–6.6M

Select item 74299055.

Arginine hypomethylation-mediated proteasomal degradation of histone H4—an early biomarker of cellular senescence

Cong Lin, Hongxin Li, Jiwei Liu, Qianying Hu, Shuai Zhang, Na Zhang, Lingxia Liu, Yingjie Dai, Donghui Cao, Xiaoxue Li, Baiqu Huang, Jun Lu, Yu Zhang

Cell Death Differ. 2020 Sep; 27(9): 2697–2709. Published online 2020 May 23. doi: 10.1038/s41418-020-0562-8

PMCID:: PMC7429905

Abstract Article PDF–4.2M

Select item 68116336.

Proteasome activator PA200 regulates myofibroblast differentiation

Vanessa Welk, Thomas Meul, Christina Lukas, Ilona E. Kammerl, Shrikant R. Mulay, Andrea C. Schamberger, Nora Semren, Isis E. Fernandez, Hans-Joachim Anders, Andreas Günther, Jürgen Behr, Oliver Eickelberg, Martina Korfei, Silke Meiners

Sci Rep. 2019; 9: 15224. Published online 2019 Oct 23. doi: 10.1038/s41598-019-51665-0

PMCID:: PMC6811633

Abstract Article PDF–2.9M

Select item 1260837.

PA200, a nuclear proteasome activator involved in DNA repair

Vicença Ustrell, Laura Hoffman, Gregory Pratt, Martin Rechsteiner

EMBO J. 2002 Jul 1; 21(13): 3516–3525. doi: 10.1093/emboj/cdf333

PMCID:: PMC126083

Abstract Article PDF–421K

Select item 76998738.

The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin

Azzam Aladdin, Yanhua Yao, Ciyu Yang, Günther Kahlert, Marvi Ghani, Nikolett Király, Anita Boratkó, Karen Uray, Gunnar Dittmar, Krisztina Tar

Biomolecules. 2020 Nov; 10(11): 1581. Published online 2020 Nov 20. doi: 10.3390/biom10111581

PMCID:: PMC7699873

Abstract Article PDF–7.2M

Select item 62543569.

Angelman syndrome–associated point mutations in the Zn²⁺-binding N-terminal (AZUL) domain of UBE3A ubiquitin ligase inhibit binding to the proteasome

Simone Kühnle, Gustavo Martínez-Noël, Flavien Leclere, Sebastian D. Hayes, J. Wade Harper, Peter M. Howley

J Biol Chem. 2018 Nov 23; 293(47): 18387–18399. Published online 2018 Sep 26. doi: 10.1074/jbc.RA118.004653

PMCID:: PMC6254356

Abstract Article PDF–1.3M

Select item 15402510.

Comprehensive Investigation of the Molecular Defect in vif-Deficient Human Immunodeficiency Virus Type 1 Virions

Nathan C. Gaddis, Elena Chertova, Ann M. Sheehy, Louis E. Henderson, Michael H. Malim

J Virol. 2003 May; 77(10): 5810–5820. doi: 10.1128/JVI.77.10.5810-5820.2003

PMCID:: PMC154025

Abstract Article PDF–1.2M

Select item 11060811.

An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif Protein

Navid Madani, David Kabat

J Virol. 1998 Dec; 72(12): 10251–10255. doi: 10.1128/jvi.72.12.10251-10255.1998

PMCID:: PMC110608

Abstract Article PDF–1.3M

Select item 135096612.

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

Hui Zhang, Bin Yang, Roger J. Pomerantz, Chune Zhang, Shyamala C. Arunachalam, Ling Gao

Nature. Author manuscript; available in PMC 2006 Jan 25.

Published in final edited form as: Nature. 2003 Jul 3; 424(6944): 94–98. Published online 2003 May 28. doi: 10.1038/nature01707

PMCID:: PMC1350966

Abstract Article PDF–355K

Select item 22935813.

The Human Immunodeficiency Virus Type 1 Vif Protein Reduces Intracellular Expression and Inhibits Packaging of APOBEC3G (CEM15), a Cellular Inhibitor of Virus Infectivity

Sandra Kao, Mohammad A. Khan, Eri Miyagi, Ron Plishka, Alicia Buckler-White, Klaus Strebel

J Virol. 2003 Nov; 77(21): 11398–11407. doi: 10.1128/JVI.77.21.11398-11407.2003

PMCID:: PMC229358

Abstract Article PDF–1.0M

Select item 732004314.

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation

Bethany Mason, Susanne Flach, Felipe R. Teixeira, Raquel Manzano Garcia, Oscar M. Rueda, Jean E. Abraham, Carlos Caldas, Paul A. W. Edwards, Heike Laman

Cell Mol Life Sci. 2020 Jul; 77(13): 2605–2620. Published online 2019 Sep 27. doi: 10.1007/s00018-019-03306-y

PMCID:: PMC7320043

Abstract Article PDF–2.5M

Select item 562506015.

The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress

Xiaorong Wang, Ilan E. Chemmama, Clinton Yu, Alexander Huszagh, Yue Xu, Rosa Viner, Sarah A. Block, Peter Cimermancic, Scott D. Rychnovsky, Yihong Ye, Andrej Sali, Lan Huang

J Biol Chem. 2017 Sep 29; 292(39): 16310–16320. Published online 2017 Aug 15. doi: 10.1074/jbc.M117.803619

PMCID:: PMC5625060

Abstract Article PDF–2.5M

Select item 541782516.

Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome

Xiaorong Wang, Peter Cimermancic, Clinton Yu, Andreas Schweitzer, Nikita Chopra, James L. Engel, Charles Greenberg, Alexander S. Huszagh, Florian Beck, Eri Sakata, Yingying Yang, Eric J. Novitsky, Alexander Leitner, Paolo Nanni, Abdullah Kahraman, Xing Guo, Jack E. Dixon, Scott D. Rychnovsky, Ruedi Aebersold, Wolfgang Baumeister, Andrej Sali, Lan Huang

Mol Cell Proteomics. 2017 May; 16(5): 840–854. Published online 2017 Mar 14. doi: 10.1074/mcp.M116.065326

PMCID:: PMC5417825

Abstract Article PDF–3.2M

Select item 863597317.

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P Hill, Clinton Yu, Lan Huang, David Fushman, Robert E Cohen, Tingting Yao

eLife. 2021; 10: e72798. Published online 2021 Nov 11. doi: 10.7554/eLife.72798

PMCID:: PMC8635973

Abstract Article PDF–10M

Select item 343450818.

Identification and Proteomic Analysis of Distinct UBE3A/E6AP Protein Complexes

Gustavo Martínez-Noël, Jeffrey T. Galligan, Mathew E. Sowa, Verena Arndt, Thomas M. Overton, J. Wade Harper, Peter M. Howley

Mol Cell Biol. 2012 Aug; 32(15): 3095–3106. doi: 10.1128/MCB.00201-12

PMCID:: PMC3434508

Abstract Article PDF–2.1M

Select item 268977919.

Affinity Purification Strategy to Capture Human Endogenous Proteasome Complexes Diversity and to Identify Proteasome-interacting Proteins

Marie-Pierre Bousquet-Dubouch, Emilie Baudelet, Frédéric Guérin, Mariette Matondo, Sandrine Uttenweiler-Joseph, Odile Burlet-Schiltz, Bernard Monsarrat

Mol Cell Proteomics. 2009 May; 8(5): 1150–1164. doi: 10.1074/mcp.M800193-MCP200

PMCID:: PMC2689779

Abstract Article PDF–406K

Select item 419392220.

Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates

Henrike C Besche, Zhe Sha, Nikolay V Kukushkin, Andreas Peth, Eva-Maria Hock, Woong Kim, Steven Gygi, Juan A Gutierrez, Hua Liao, Lawrence Dick, Alfred L Goldberg

EMBO J. 2014 May 16; 33(10): 1159–1176. Published online 2014 May 8. doi: 10.1002/embj.201386906