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Select item 99470071.

PAK2 is essential for chromosome alignment in metaphase I oocytes

Juan Zeng, Shiwei Wang, Min Gao, Dian Lu, Shuang Song, Diyu Chen, Weimin Fan, Zhiliang Xu, Zhiguo Zhang, Xiaofang Sun

Cell Death Dis. 2023 Feb; 14(2): 150. Published online 2023 Feb 22. doi: 10.1038/s41419-023-05585-7

PMCID:: PMC9947007

Abstract Article PDF–5.3M

Select item 89578202.

Pak2 Regulation of Nrf2 Serves as a Novel Signaling Nexus Linking ER Stress Response and Oxidative Stress in the Heart

Pablo Binder, Binh Nguyen, Lucy Collins, Min Zi, Wei Liu, Foteini Christou, Xiaojing Luo, Susanne S. Hille, Norbert Frey, Elizabeth J. Cartwright, Jonathan Chernoff, Oliver J. Müller, Kaomei Guan, Xin Wang

Front Cardiovasc Med. 2022; 9: 851419. Published online 2022 Mar 8. doi: 10.3389/fcvm.2022.851419

PMCID:: PMC8957820

Abstract Article PDF–3.8M

Select item 89053203.

Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

Namrita Kaur, Andrea Ruiz-Velasco, Rida Raja, Gareth Howell, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Kimberly Mace, Susanne S. Hille, Norbert Frey, Pablo Binder, Craig P. Smith, Helene Fachim, Handrean Soran, Eileithyia Swanton, Tamer M.A. Mohamed, Oliver J. Müller, Xin Wang, Jonathan Chernoff, Elizabeth J. Cartwright, Wei Liu

iScience. 2022 Mar 18; 25(3): 103973. Published online 2022 Feb 23. doi: 10.1016/j.isci.2022.103973

PMCID:: PMC8905320

Abstract Article PDF–6.4M

Select item 86560774.

Pak2 reduction induces a failure of early embryonic development in mice

Juan Zeng, Nengqing Liu, Yinghong Yang, Yi Cheng, Yuanshuai Li, Xiaoxia Guo, Qian Luo, Lifen Zhu, Hongmei Guan, Bing Song, Xiaofang Sun

Reprod Biol Endocrinol. 2021; 19: 181. Published online 2021 Dec 9. doi: 10.1186/s12958-021-00865-3

PMCID:: PMC8656077

Abstract Article PDF–1.5M

Select item 44244195.

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization

Rachelle E. Kosoff, Joseph E. Aslan, John C. Kostyak, Essel Dulaimi, Hoi Yee Chow, Tatiana Y. Prudnikova, Maria Radu, Satya P. Kunapuli, Owen J. T. McCarty, Jonathan Chernoff

Blood. 2015 May 7; 125(19): 2995–3005. Prepublished online 2015 Mar 30. doi: 10.1182/blood-2014-10-604504

PMCID:: PMC4424419

Abstract Article

Select item 44095596.

Pak2 regulates hematopoietic progenitor cell proliferation, survival and differentiation

Yi Zeng, Hal E. Broxmeyer, Karl Staser, Brahmananda Reddy Chitteti, Su-Jung Park, Seongmin Hahn, Scott Cooper, Zejin Sun, Li Jiang, XianLin Yang, Jin Yuan, Rachelle Kosoff, George Sandusky, Edward F. Srour, Jonathan Chernoff, Wade Clapp

Stem Cells. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Stem Cells. 2015 May; 33(5): 1630–1641. doi: 10.1002/stem.1951

PMCID:: PMC4409559

Abstract Article PDF–3.0M

Select item 40176457.

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation

Hyewon Phee, Byron B Au-Yeung, Olga Pryshchep, Kyle Leonard O'Hagan, Stephanie Grace Fairbairn, Maria Radu, Rachelle Kosoff, Marianne Mollenauer, Debra Cheng, Jonathan Chernoff, Arthur Weiss

eLife. 2014; 3: e02270. Published online 2014 May 13. doi: 10.7554/eLife.02270

PMCID:: PMC4017645

Abstract Article PDF–3.2M

Select item 11405848.

Outgrowth of Neurites from NIE-115 Neuroblastoma Cells Is Prevented on Repulsive Substrates through the Action of PAK

Katharine J. M. Marler, Robert Kozma, Sohail Ahmed, Jing-Ming Dong, Christine Hall, Louis Lim

Mol Cell Biol. 2005 Jun; 25(12): 5226–5241. doi: 10.1128/MCB.25.12.5226-5241.2005

PMCID:: PMC1140584

Abstract Article PDF–1.3M

Select item 90812589.

Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling

Eleonora Sementino, Yuwaraj Kadariya, Mitchell Cheung, Craig W. Menges, Yinfei Tan, Anna-Mariya Kukuyan, Ujjawal Shrestha, Sofiia Karchugina, Kathy Q. Cai, Suraj Peri, James S. Duncan, Jonathan Chernoff, Joseph R. Testa

Mol Cancer Res. Author manuscript; available in PMC 2022 Nov 4.

Published in final edited form as: Mol Cancer Res. 2022 May 4; 20(5): 699–711. doi: 10.1158/1541-7786.MCR-21-0837

PMCID:: PMC9081258

Abstract Article PDF–2.3M

Select item 732298310.

The p21‐activated kinase 2 (PAK2), but not PAK1, regulates contraction‐stimulated skeletal muscle glucose transport

Lisbeth L. V. Møller, Ida L. Nielsen, Jonas R. Knudsen, Nicoline R. Andersen, Thomas E. Jensen, Lykke Sylow, Erik A. Richter

Physiol Rep. 2020 Jun; 8(12): e14460. Published online 2020 Jun 29. doi: 10.14814/phy2.14460

PMCID:: PMC7322983

Abstract Article PDF–2.1M

Select item 661328411.

Pak2 kinase promotes cellular senescence and organismal aging

Jong-Sun Lee, Yan Mo, Haiyun Gan, Rebecca J. Burgess, Darren J. Baker, Jan M. van Deursen, Zhiguo Zhang

Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13311–13319. Published online 2019 Jun 17. doi: 10.1073/pnas.1903847116

PMCID:: PMC6613284

Abstract Article PDF–2.0M

Select item 640783012.

Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response

Pablo Binder, Shunyao Wang, Maria Radu, Min Zin, Lucy Collins, Saba Khan, Yatong Li, Karolina Sekeres, Neil Humphreys, Eileithyia Swanton, Adam Reid, Fay Pu, Delvac Oceandy, Kaomei Guan, Susanne S. Hille, Norbert Frey, Oliver J. Müller, Elizabeth J. Cartwright, Jonathan Chernoff, Xin Wang, Wei Liu

Circ Res. 2019 Mar 1; 124(5): 696–711. Published online 2019 Feb 28. doi: 10.1161/CIRCRESAHA.118.312829

PMCID:: PMC6407830

Abstract Article PDF–8.9M

Select item 571904813.

Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype

Kyle L. O’Hagan, Stephen D. Miller, Hyewon Phee

Sci Rep. 2017; 7: 17097. Published online 2017 Dec 6. doi: 10.1038/s41598-017-17078-7

PMCID:: PMC5719048

Abstract Article PDF–5.7M

Select item 484104014.

p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix

Pavankumar N. G. Reddy, Maria Radu, Ke Xu, Jenna Wood, Chad E. Harris, Jonathan Chernoff, David A. Williams

Blood. 2016 Apr 21; 127(16): 1967–1975. Prepublished online 2016 Mar 1. doi: 10.1182/blood-2016-01-693572

PMCID:: PMC4841040

Abstract Article

Select item 354304715.

Pak2 Kinase Restrains Mast Cell FcϵRI Receptor Signaling through Modulation of Rho Protein Guanine Nucleotide Exchange Factor (GEF) Activity

Rachelle Kosoff, Hoi Yee Chow, Maria Radu, Jonathan Chernoff

J Biol Chem. 2013 Jan 11; 288(2): 974–983. Published online 2012 Nov 30. doi: 10.1074/jbc.M112.422295

PMCID:: PMC3543047

Abstract Article PDF–1.4M

Select item 989603416.

Loss‐of‐Function of p21‐Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects

Yan Wang, Kaifan Zhang, Jin Guo, Shuyan Yang, Xiaohui Shi, Jinrong Pan, Zheng Sun, Jizhen Zou, Yi Li, Yuanyuan Li, Tianda Fan, Wei Song, Fang Cheng, Cheng Zeng, Jinchen Li, Ting Zhang, Zhong Sheng Sun

Adv Sci (Weinh) 2023 Feb; 10(4): 2204018. Published online 2022 Dec 11. doi: 10.1002/advs.202204018

PMCID:: PMC9896034

Abstract Article PDF–4.9M

Select item 951004617.

Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

Mahesh Kathania, Ritesh Kumar, Elviche Taskem Lenou, Venkatesha Basrur, Arianne L. Theiss, Jonathan Chernoff, K. Venuprasad

Cell Rep. Author manuscript; available in PMC 2022 Sep 25.

Published in final edited form as: Cell Rep. 2022 Sep 13; 40(11): 111345. doi: 10.1016/j.celrep.2022.111345

PMCID:: PMC9510046

Abstract Article PDF–1.4M

Select item 836983818.

PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2)

Eric Hawley, Jeffrey Gehlhausen, Sofiia Karchugina, Hoi-Yee Chow, Daniela Araiza-Olivera, Maria Radu, Abbi Smith, Ciersten Burks, Li Jiang, Xiaohong Li, Waylan Bessler, Andrea Masters, Donna Edwards, Callie Burgin, David Jones, Charles Yates, D Wade Clapp, Jonathan Chernoff, Su-Jung Park

Hum Mol Genet. 2021 Sep 1; 30(17): 1607–1617. Published online 2021 Jun 1. doi: 10.1093/hmg/ddab106

PMCID:: PMC8369838

Abstract Article PDF–1.6M

Select item 715641119.

The dynactin subunit DCTN1 controls osteoclastogenesis via the Cdc42/PAK2 pathway

Yong Deok Lee, Bongjun Kim, Suhan Jung, Haemin Kim, Min Kyung Kim, Jun-Oh Kwon, Min-Kyoung Song, Zang Hee Lee, Hong-Hee Kim

Exp Mol Med. 2020 Mar; 52(3): 514–528. Published online 2020 Mar 24. doi: 10.1038/s12276-020-0406-0

PMCID:: PMC7156411

Abstract Article PDF–7.4M

Select item 680260920.

MicroRNA-455-3p promotes TGF-β signaling and inhibits osteoarthritis development by directly targeting PAK2

Shu Hu, Xiaoyi Zhao, Guping Mao, Ziji Zhang, Xingzhao Wen, Chengyun Zhang, Weiming Liao, Zhiqi Zhang

Exp Mol Med. 2019 Oct; 51(10): 118. Published online 2019 Oct 4. doi: 10.1038/s12276-019-0322-3

PMCID:: PMC6802609

Abstract Article PDF–2.4M

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