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Select item 109817851.

Tumor suppressor protein p53 negatively regulates ischemia-induced angiogenesis and arteriogenesis

Miles J. Pfaff, Subhradip Mukhopadhyay, Mark Hoofnagle, Christine Chabasse, Rajabrata Sarkar

J Vasc Surg. Author manuscript; available in PMC 2024 Mar 31.

Published in final edited form as: J Vasc Surg. 2018 Dec; 68(6 Suppl): 222S–233S.e1. Published online 2018 Aug 17. doi: 10.1016/j.jvs.2018.02.055

PMCID:: PMC10981785

Abstract Article PDF–1.4M

Select item 109579102.

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

Ross J. Hill, Nazareno Bona, Job Smink, Hannah K. Webb, Alastair Crisp, Juan I. Garaycoechea, Gerry P. Crossan

Nat Commun. 2024; 15: 2518. Published online 2024 Mar 21. doi: 10.1038/s41467-024-46844-1

PMCID:: PMC10957910

Abstract Article PDF–7.8M

Select item 108509473.

Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang, Matteo Burigotto, Sabrina Ghetti, François Vaillant, Tao Tan, Bianca D. Capaldo, Michelle Palmieri, Yumiko Hirokawa, Lin Tai, Daniel S. Simpson, Catherine Chang, Allan Shuai Huang, Elizabeth Lieschke, Sarah T. Diepstraten, Deeksha Kaloni, Chris Riffkin, David C.S. Huang, Connie S.N. Li Wai Suen, Alexandra L. Garnham, Peter Gibbs, Jane E. Visvader, Oliver M. Sieber, Marco J. Herold, Luca L. Fava, Gemma L. Kelly, Andreas Strasser

Cancer Discov. 2024 Feb 8; 14(2): 362–379. Published online 2023 Oct 24. doi: 10.1158/2159-8290.CD-23-0402

PMCID:: PMC10850947

Abstract Article PDF–17M

Select item 107666054.

Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms

Panhong Gou, Duanya Liu, Saravanan Ganesan, Evelyne Lauret, Nabih Maslah, Veronique Parietti, Wenchao Zhang, Véronique Meignin, Jean-Jacques Kiladjian, Bruno Cassinat, Stephane Giraudier

Blood Cancer J. 2024 Dec; 14(1): 1. Published online 2024 Jan 4. doi: 10.1038/s41408-023-00969-6

PMCID:: PMC10766605

Abstract Article PDF–4.1M

Select item 107586905.

Gain-of-Function p53 Mutation Acts as a Genetic Switch for TGFβ Signaling–Induced Epithelial-to-Mesenchymal Transition in Intestinal Tumors

Dong Wang, Mizuho Nakayama, Chang Pyo Hong, Hiroko Oshima, Masanobu Oshima

Cancer Res. 2024 Jan 2; 84(1): 56–68. Published online 2023 Oct 18. doi: 10.1158/0008-5472.CAN-23-1490

PMCID:: PMC10758690

Abstract Article PDF–14M

Select item 106872306.

Arsenic trioxide extends survival of Li–Fraumeni syndrome mimicking mouse

Jiabing Li, Shujun Xiao, Fangfang Shi, Huaxin Song, Jiaqi Wu, Derun Zheng, Xueqin Chen, Kai Tan, Min Lu

Cell Death Dis. 2023 Nov; 14(11): 783. Published online 2023 Nov 29. doi: 10.1038/s41419-023-06281-2

PMCID:: PMC10687230

Abstract Article PDF–2.1M

Select item 106467837.

The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53

Maria-Riera Piqué-Borràs, Zivojin Jevtic, Frederik Otzen Bagger, Jonathan Seguin, Rathick Sivalingam, Matheus Filgueira Bezerra, Amber Louwagie, Sabine Juge, Ioannis Nellas, Robert Ivanek, Alexandar Tzankov, Ute M. Moll, Oriano Cantillo, Ramona Schulz-Heddergott, Alexandre Fagnan, Thomas Mercher, Juerg Schwaller

Blood. 2023 May 4; 141(18): 2245–2260. Published online 2023 Feb 8. doi: 10.1182/blood.2022017273

PMCID:: PMC10646783

Abstract Article

Select item 106449008.

TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

Iker Ausejo-Mauleon, Sara Labiano, Daniel de la Nava, Virginia Laspidea, Marta Zalacain, Lucía Marrodán, Marc García-Moure, Marisol González-Huarriz, Irati Hervás-Corpión, Laasya Dhandapani, Silvestre Vicent, Maria Collantes, Iván Peñuelas, Oren J. Becher, Mariella G. Filbin, Li Jiang, Jenna Labelle, Carlos A.O. de Biagi-Junior, Javad Nazarian, Sandra Laternser, Timothy N. Phoenix, Jasper van der Lugt, Mariette Kranendonk, Raoull Hoogendijk, Sabine Mueller, Carlos De Andrea, Ana C. Anderson, Elizabeth Guruceaga, Carl Koschmann, Viveka Nand Yadav, Jaime Gállego Pérez-Larraya, Ana Patiño-García, Fernando Pastor, Marta M. Alonso

Cancer Cell. 2023 Nov 13; 41(11): 1911–1926.e8. doi: 10.1016/j.ccell.2023.09.001

PMCID:: PMC10644900

Abstract Article

Select item 104457399.

A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes

Laura Schubert, Anh T. Le, Trista K. Hinz, Andre C. Navarro, Sarah K. Nelson-Taylor, Raphael A. Nemenoff, Lynn E. Heasley, Robert C. Doebele

Biol Open. 2023 Aug 15; 12(8): bio059994. Published online 2023 Aug 15. doi: 10.1242/bio.059994

PMCID:: PMC10445739

Abstract Article PDF–5.9M

Select item 1044056410.

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation

Judith Niesen, Irm Hermans-Borgmeyer, Christina Krüger, Melanie Schoof, Franziska Modemann, Ulrich Schüller

iScience. 2023 Sep 15; 26(9): 107501. Published online 2023 Jul 28. doi: 10.1016/j.isci.2023.107501

PMCID:: PMC10440564

Abstract Article PDF–5.3M

Select item 1010151911.

Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice

Richard J. Epstein, Frank P. Y. Lin, Robert A. Brink, James Blackburn

PLoS One. 2023; 18(4): e0284327. Published online 2023 Apr 13. doi: 10.1371/journal.pone.0284327

PMCID:: PMC10101519

Abstract Article PDF–772K

Select item 1006875912.

Proteasome inhibitor bortezomib stabilizes and activates p53 in hematopoietic stem/progenitors and double-negative T cells in vivo

Yuezhen Xue, Boris San Luis, Regine J. Dress, Katzrin Binte Ahmad Murad, Florent Ginhoux, Nick Barker, David Lane

Proc Natl Acad Sci U S A. 2023 Mar 28; 120(13): e2219978120. Published online 2023 Mar 20. doi: 10.1073/pnas.2219978120

PMCID:: PMC10068759

Abstract Article PDF–19M

Select item 1001880513.

Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

Rajappa S. Kenchappa, Athanassios Dovas, Michael G. Argenziano, Christian T. Meyer, Lauren E. Stopfer, Matei A. Banu, Brianna Pereira, Jessica Griffith, Afroz Mohammad, Surabhi Talele, Ashley Haddock, Natanael Zarco, William Elmquist, Forest White, Vito Quaranta, Peter Sims, Peter Canoll, Steven S. Rosenfeld

Cell Rep. Author manuscript; available in PMC 2023 Mar 16.

Published in final edited form as: Cell Rep. 2022 Jun 21; 39(12): 110991. doi: 10.1016/j.celrep.2022.110991

PMCID:: PMC10018805

Abstract Article PDF–2.7M

Select item 997338214.

Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53 Aneuploidy–driven Metabolic Reprogramming

Marni B. McClure, Yasunori Kogure, Naser Ansari-Pour, Yuki Saito, Hann-Hsiang Chao, Jonathan Shepherd, Mariko Tabata, Olufunmilayo I. Olopade, David C. Wedge, Katherine A. Hoadley, Charles M. Perou, Keisuke Kataoka

Cancer Res Commun. 2023 Feb; 3(2): 281–296. Published online 2023 Feb 16. doi: 10.1158/2767-9764.CRC-22-0073

PMCID:: PMC9973382

Abstract Article PDF–10M

Select item 983283815.

IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

Xiaoxiao Liu, Naru Sato, Tomohiro Yabushita, Jingmei Li, Yuhan Jia, Moe Tamura, Shuhei Asada, Takeshi Fujino, Tsuyoshi Fukushima, Taishi Yonezawa, Yosuke Tanaka, Tomofusa Fukuyama, Akiho Tsuchiya, Shiori Shikata, Hiroyuki Iwamura, Chieko Kinouchi, Kensuke Komatsu, Satoshi Yamasaki, Tatsuhiro Shibata, Atsuo T Sasaki, Janet Schibler, Mark Wunderlich, Eric O'Brien, Benjamin Mizukawa, James C Mulloy, Yuki Sugiura, Hitoshi Takizawa, Takuma Shibata, Kensuke Miyake, Toshio Kitamura, Susumu Goyama

EMBO Mol Med. 2023 Jan; 15(1): e15631. Published online 2022 Dec 1. doi: 10.15252/emmm.202115631

PMCID:: PMC9832838

Abstract Article PDF–5.8M

Select item 982150616.

Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice

Na-Won Kim, Sun-Min Seo, Eun-Seon Yoo, Ah-Reum Kang, Ji-Hun Lee, Jae-Hoon Lee, Byeong-Cheol Kang, Han-Woong Lee, Yang-Kyu Choi

PLoS One. 2023; 18(1): e0280214. Published online 2023 Jan 6. doi: 10.1371/journal.pone.0280214

PMCID:: PMC9821506

Abstract Article PDF–3.0M

Select item 968835317.

Depletion of R270C Mutant p53 in Osteosarcoma Attenuates Cell Growth but Does Not Prevent Invasion and Metastasis In Vivo

Takatsune Shimizu, Eiji Sugihara, Hideyuki Takeshima, Hiroyuki Nobusue, Rui Yamaguchi, Sayaka Yamaguchi-Iwai, Yumi Fukuchi, Toshikazu Ushijima, Akihiro Muto, Hideyuki Saya

Cells. 2022 Nov; 11(22): 3614. Published online 2022 Nov 15. doi: 10.3390/cells11223614

PMCID:: PMC9688353

Abstract Article PDF–3.9M

Select item 964339618.

Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

Seref Gul, Yasemin Kubra Akyel, Zeynep Melis Gul, Safak Isin, Onur Ozcan, Tuba Korkmaz, Saba Selvi, Ibrahim Danis, Ozgecan Savlug Ipek, Fatih Aygenli, Ali Cihan Taskin, Büşra Aytül Akarlar, Nurhan Ozlu, Nuri Ozturk, Narin Ozturk, Durişehvar Özer Ünal, Mustafa Guzel, Metin Turkay, Alper Okyar, Ibrahim Halil Kavakli

Nat Commun. 2022; 13: 6742. Published online 2022 Nov 8. doi: 10.1038/s41467-022-34582-1

PMCID:: PMC9643396

Abstract Article PDF–3.0M

Select item 958494919.

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A. Hall, Moritz Gerstung, Philip H. Jones

Nat Commun. 2022; 13: 6206. Published online 2022 Oct 20. doi: 10.1038/s41467-022-33945-y

PMCID:: PMC9584949

Abstract Article PDF–3.7M

Select item 947960320.

Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade

Arnab Ghosh, Judith Michels, Riccardo Mezzadra, Divya Venkatesh, Lauren Dong, Ricardo Gomez, Fadi Samaan, Yu-Jui Ho, Luis Felipe Campesato, Levi Mangarin, John Fak, Nathan Suek, Aliya Holland, Cailian Liu, Mohsen Abu-Akeel, Yonina Bykov, Hong Zhong, Kelly Fitzgerald, Sadna Budhu, Andrew Chow, Roberta Zappasodi, Katherine S. Panageas, Olivier de Henau, Marcus Ruscetti, Scott W. Lowe, Taha Merghoub, Jedd D. Wolchok

J Clin Invest. 2022 Sep 15; 132(18): e148141. Published online 2022 Sep 15. doi: 10.1172/JCI148141

PMCID:: PMC9479603

Abstract Article PDF–2.2M

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