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Select item 108248741.

Sphingomyelin synthase 2 promotes the stemness of breast cancer cells via modulating NF-κB signaling pathway

Haizhan Feng, Yahui Dong, Kunling Chen, Zicong You, Junyan Weng, Peiqiao Liang, Fujun Shi

J Cancer Res Clin Oncol. 2024; 150(2): 46. Published online 2024 Jan 29. doi: 10.1007/s00432-023-05589-y

PMCID:: PMC10824874

Abstract Article PDF–6.1M

Select item 105988462.

SGMS2 in primary osteoporosis with facial nerve palsy

Sandra Pihlström, Sampo Richardt, Kirsi Määttä, Minna Pekkinen, Vesa M. Olkkonen, Outi Mäkitie, Riikka E. Mäkitie

Front Endocrinol (Lausanne) 2023; 14: 1224318. Published online 2023 Oct 11. doi: 10.3389/fendo.2023.1224318

PMCID:: PMC10598846

Abstract Article PDF–1.7M

Select item 101785753.

Clinical and Genetic Characteristics of Calvarial Doughnut Lesions with Bone Fragility in Three Families with a Reccurent SGMS2 Gene Variant

Elena Merkuryeva, Tatiana Markova, Anton Tyurin, Diana Valeeva, Vladimir Kenis, Maria Sumina, Igor Sorokin, Olga Shchagina, Mikhail Skoblov, Maria Nefedova, Rita Khusainova, Ekaterina Zakharova, Elena Dadali, Sergey Kutsev

Int J Mol Sci. 2023 May; 24(9): 8021. Published online 2023 Apr 28. doi: 10.3390/ijms24098021

PMCID:: PMC10178575

Abstract Article PDF–2.1M

Select item 79380994.

Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study

Asahi Hishida, Masahiro Nakatochi, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Mineko Tsukamoto, Yuka Kadomatsu, Sadao Suzuki, Takeshi Nishiyama, Nagato Kuriyama, Isao Watanabe, Toshiro Takezaki, Daisaku Nishimoto, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Haruo Mikami, Miho Kusakabe, Isao Oze, Yuriko N. Koyanagi, Yasuyuki Nakamura, Aya Kadota, Chisato Shimanoe, Keitaro Tanaka, Hiroaki Ikezaki, Masayuki Murata, Michiaki Kubo, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai, for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group

Nagoya J Med Sci. 2021 Feb; 83(1): 183–194. doi: 10.18999/nagjms.83.1.183

PMCID:: PMC7938099

Abstract Article PDF–3.6M

Select item 79216605.

Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer

Yan Deng, Jia-chun Hu, Shu-hua He, Bin Lou, Ting-bo Ding, Jin-tong Yang, Ming-guang Mo, De-yong Ye, Lu Zhou, Xian-cheng Jiang, Ker Yu, Ji-bin Dong

Acta Pharmacol Sin. 2021 Jan; 42(1): 149–159. Published online 2020 May 25. doi: 10.1038/s41401-020-0419-1

PMCID:: PMC7921660

Abstract Article PDF–4.7M

Select item 66273056.

Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress

Lingyue Hua, Na Wu, Ruilin Zhao, Xuanhong He, Qian Liu, Xiatian Li, Zhiqiang He, Lehan Yu, Nianlong Yan

Int J Mol Sci. 2019 Jun; 20(12): 2861. Published online 2019 Jun 12. doi: 10.3390/ijms20122861

PMCID:: PMC6627305

Abstract Article PDF–2.9M

Select item 63776187.

Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disrupting the homoeostasis of ceramide and sphingomyelin

Kehong Zheng, Zetao Chen, Haizhan Feng, Ying Chen, Cheng Zhang, Jinlong Yu, Yunfeng Luo, Liang Zhao, Xiancheng Jiang, Fujun Shi

Cell Death Dis. 2019 Mar; 10(3): 157. Published online 2019 Feb 15. doi: 10.1038/s41419-019-1303-0

PMCID:: PMC6377618

Abstract Article PDF–2.4M

Select item 30327238.

Adenovirus-mediated sphingomyelin synthase 2 increases atherosclerotic lesions in ApoE KO mice

Xiaogang Wang, Jibin Dong, Yarui Zhao, Yue Li, Manping Wu

Lipids Health Dis. 2011; 10: 7. Published online 2011 Jan 17. doi: 10.1186/1476-511X-10-7

PMCID:: PMC3032723

Abstract Article PDF–1.4M

Select item 27598339.

Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase

Philipp Ternes, Jos F. H. M. Brouwers, Joep van den Dikkenberg, Joost C. M. Holthuis

J Lipid Res. 2009 Nov; 50(11): 2270–2277. doi: 10.1194/jlr.M900230-JLR200

PMCID:: PMC2759833

Abstract Article PDF–893K

Select item 705569510.

Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke

Gayatri Gupta, Nathalie Baumlin, Justin Poon, Begum Ahmed, Yeun-Po Chiang, Christopher Railwah, Michael D. Kim, Melissa Rivas, Hannah Goldenberg, Ziyad Elgamal, Matthias Salathe, Apurav A. Panwala, Abdoulaye Dabo, Chongmin Huan, Robert Foronjy, Xian-Cheng Jiang, Raj Wadgaonkar, Patrick Geraghty

Am J Respir Cell Mol Biol. 2020 Mar; 62(3): 342–353. doi: 10.1165/rcmb.2019-0133OC

PMCID:: PMC7055695

Abstract Article PDF–1.5M

Select item 648364111.

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Minna Pekkinen, Paulien A. Terhal, Lorenzo D. Botto, Petra Henning, Riikka E. Mäkitie, Paul Roschger, Amrita Jain, Matthijs Kol, Matti A. Kjellberg, Eleftherios P. Paschalis, Koen van Gassen, Mary Murray, Pinar Bayrak-Toydemir, Maria K. Magnusson, Judith Jans, Mehran Kausar, John C. Carey, Pentti Somerharju, Ulf H. Lerner, Vesa M. Olkkonen, Klaus Klaushofer, Joost C.M. Holthuis, Outi Mäkitie

JCI Insight. 2019 Apr 4; 4(7): e126180. Published online 2019 Apr 4. doi: 10.1172/jci.insight.126180

PMCID:: PMC6483641

Abstract Article PDF–1.4M

Select item 524764612.

Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum

Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Takashi Tanikawa, Saori Oka, Yusuke Tanaka, Seisuke Arai, Ikuo Wada, Takayuki Sugiura, Atsushi Yamashita

J Biol Chem. 2017 Jan 20; 292(3): 1122–1141. Published online 2016 Dec 7. doi: 10.1074/jbc.M116.746602

PMCID:: PMC5247646

Abstract Article PDF–3.8M

Select item 512509013.

Sphingomyelin synthases regulate production of diacylglycerol at the Golgi

Maristella Villani, Marimuthu Subathra, Yeong-Bin Im, Young Choi, Paola Signorelli, Maurizio Del Poeta, Chiara Luberto

Biochem J. Author manuscript; available in PMC 2016 Nov 28.

Published in final edited form as: Biochem J. 2008 Aug 15; 414(1): 31–41. doi: 10.1042/BJ20071240

PMCID:: PMC5125090

Abstract Article PDF–4.2M

Select item 342683114.

The Domain Responsible for Sphingomyelin Synthase (SMS) Activity

Calvin Yeang, Shweta Varsheny, Renxiao Wang, Ya Zhang, Deyong Ye, Xian-Cheng Jiang

Biochim Biophys Acta. Author manuscript; available in PMC 2012 Aug 24.

Published in final edited form as: Biochim Biophys Acta. 2008 Oct; 1781(10): 610–617. Published online 2008 Jul 23. doi: 10.1016/j.bbalip.2008.07.002

PMCID:: PMC3426831

Abstract Article PDF–2.5M

Select item 324178715.

Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

Gwendolyn Barceló-Coblijn, Maria Laura Martin, Rodrigo F. M. de Almeida, Maria Antònia Noguera-Salvà, Amaia Marcilla-Etxenike, Francisca Guardiola-Serrano, Anja Lüth, Burhard Kleuser, John E. Halver, Pablo V. Escribá

Proc Natl Acad Sci U S A. 2011 Dec 6; 108(49): 19569-19574. Published online 2011 Nov 21. doi: 10.1073/pnas.1115484108

PMCID:: PMC3241787

Abstract Article PDF–663K

Select item 276355316.

Sphingomyelin synthase 2 (SMS2) is one of the determinants for plasma and liver sphingomyelin levels in mice

Jing Liu, Hongqi Zhang, Zhiqiang Li, Tiruneh K. Hailemariam, Mahua Chakraborty, Daniel Qiu, Hai H. Bui, David A. Peake, Ming-Shang Kuo, Raj Wadgaonkar, Guoqing Cao, Xian-Cheng Jiang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2010 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6): 850–856. Published online 2009 Mar 12. doi: 10.1161/ATVBAHA.109.185223

PMCID:: PMC2763553

Abstract Article PDF–698K

Select item 271282217.

Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization

Zhiqiang Li, Tiruneh K. Hailemariam, Hongwen Zhou, Yan Li, Dale C. Duckworth, David A. Peake, Youyan Zhang, Ming-Shang Kuo, Guoqing Cao, Xian-Cheng Jiang

Biochim Biophys Acta. Author manuscript; available in PMC 2009 Jul 20.

Published in final edited form as: Biochim Biophys Acta. 2007 Sep; 1771(9): 1186–1194. Published online 2007 Jun 6. doi: 10.1016/j.bbalip.2007.05.007

PMCID:: PMC2712822

Abstract Article PDF–1.3M

Select item 987232018.

LARP6 suppresses colorectal cancer progression through ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis

Xiaoli Long, Xunhua Liu, Ting Deng, Jianxiong Chen, Jiawen Lan, Sijing Zhang, Miao Zhou, Dan Guo, Jun Zhou

J Exp Clin Cancer Res. 2023; 42: 33. Published online 2023 Jan 24. doi: 10.1186/s13046-023-02605-4

PMCID:: PMC9872320

Abstract Article PDF–19M

Select item 318125019.

Sphingomyelin Synthases Regulate Protein Trafficking and Secretion

Marimuthu Subathra, Asfia Qureshi, Chiara Luberto

PLoS One. 2011; 6(9): e23644. Published online 2011 Sep 27. doi: 10.1371/journal.pone.0023644

PMCID:: PMC3181250

Abstract Article PDF–903K

Select item 261366320.

An Inositolphosphorylceramide Synthase Is Involved in Regulation of Plant Programmed Cell Death Associated with Defense in Arabidopsis

Wenming Wang, Xiaohua Yang, Samantha Tangchaiburana, Roland Ndeh, Jonathan E. Markham, Yoseph Tsegaye, Teresa M. Dunn, Guo-Liang Wang, Maria Bellizzi, James F. Parsons, Danielle Morrissey, Janis E. Bravo, Daniel V. Lynch, Shunyuan Xiao

Plant Cell. 2008 Nov; 20(11): 3163–3179. doi: 10.1105/tpc.108.060053

PMCID:: PMC2613663

Abstract Article PDF–1.4M

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