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Select item 95878341.

Targeted Proteins Reveal Cathepsin D as a Novel Biomarker in Differentiating Hepatocellular Carcinoma from Cirrhosis and Other Liver Cancers

Natthaya Chuaypen, Supachaya Sriphoosanaphan, Athaya Vorasittha, Nutcha Pinjaroen, Sakdithep Chaiyarit, Visith Thongboonkerd, Pisit Tangkijvanich, Pongserath Sirichindakul

Asian Pac J Cancer Prev. 2022 Jun; 23(6): 2017–2025. doi: 10.31557/APJCP.2022.23.6.2017

PMCID:: PMC9587834

Abstract Article PDF–524K

Select item 91011732.

High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth

Eleonora Secomandi, Amreen Salwa, Chiara Vidoni, Alessandra Ferraresi, Carlo Follo, Ciro Isidoro

Int J Mol Sci. 2022 May; 23(9): 4782. Published online 2022 Apr 26. doi: 10.3390/ijms23094782

PMCID:: PMC9101173

Abstract Article PDF–1.6M

Select item 85800763.

The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease

Juan Yang, Xiaoting Ding, Shasha Meng, Jinhua Cai, Weihui Zhou

Mol Genet Genomic Med. 2021 Oct; 9(10): e1777. Published online 2021 Jul 31. doi: 10.1002/mgg3.1777

PMCID:: PMC8580076

Abstract Article PDF–1.1M

Select item 81678724.

Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6‐phosphate pathway

Lin Liu, Balraj Doray

FEBS Open Bio. 2021 Jun; 11(6): 1695–1703. Published online 2021 May 5. doi: 10.1002/2211-5463.13169

PMCID:: PMC8167872

Abstract Article PDF–2.2M

Select item 80282635.

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration

Yuek Ling Chai, Joyce R. Chong, Jiaju Weng, David Howlett, Andrea Halsey, Jasinda H. Lee, Johannes Attems, Dag Aarsland, Paul T. Francis, Christopher P. Chen, Mitchell K.P. Lai

Brain Pathol. 2019 Jan; 29(1): 63–74. Published online 2018 Oct 17. doi: 10.1111/bpa.12631

PMCID:: PMC8028263

Abstract Article PDF–676K

Select item 78271756.

Identification of Cathepsin D as a Plasma Biomarker for Alzheimer’s Disease

Jae-Whan Kim, Soon-Young Jung, Youngbin Kim, Hansol Heo, Chang-Hyung Hong, Sang-Won Seo, Seong-Hye Choi, Sang-Joon Son, Seongju Lee, Jaerak Chang

Cells. 2021 Jan; 10(1): 138. Published online 2021 Jan 12. doi: 10.3390/cells10010138

PMCID:: PMC7827175

Abstract Article PDF–2.1M

Select item 74927917.

Expression profiling of precuneus layer III cathepsin D-immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer’s disease: Evidence for neuronal signaling vulnerability

Bin He, Sylvia E. Perez, Sang Han Lee, Stephen D. Ginsberg, Michael Malek-Ahmadi, Elliott J. Mufson

J Comp Neurol. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: J Comp Neurol. 2020 Nov 1; 528(16): 2748–2766. Published online 2020 May 5. doi: 10.1002/cne.24929

PMCID:: PMC7492791

Abstract Article PDF–1.2M

Select item 74574718.

Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study

Hayoung Choi, Yousang Ko, Chang Youl Lee

BMC Cancer. 2020; 20: 825. Published online 2020 Aug 31. doi: 10.1186/s12885-020-07327-w

PMCID:: PMC7457471

Abstract Article PDF–767K

Select item 70755749.

Myocardial cathepsin D is downregulated in sudden cardiac death

Yu Kakimoto, Ayumi Sasaki, Maki Niioka, Noboru Kawabe, Motoki Osawa

PLoS One. 2020; 15(3): e0230375. Published online 2020 Mar 16. doi: 10.1371/journal.pone.0230375

PMCID:: PMC7075574

Abstract Article PDF–1.6M

Select item 706287110.

Neuroprotective Effects of Necrostatin-1 Against Oxidative Stress–Induced Cell Damage: an Involvement of Cathepsin D Inhibition

Danuta Jantas, Jakub Chwastek, Beata Grygier, Władysław Lasoń

Neurotox Res. 2020; 37(3): 525–542. Published online 2020 Jan 21. doi: 10.1007/s12640-020-00164-6

PMCID:: PMC7062871

Abstract Article PDF–3.1M

Select item 574244111.

Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes

Lei Liu, Baoxian Chen, Xudong Zhang, Lun Tan, Dao Wen Wang

Dis Markers. 2017; 2017: 5286408. Published online 2017 Dec 10. doi: 10.1155/2017/5286408

PMCID:: PMC5742441

Abstract Article PDF–666K

Select item 534397012.

Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D

Yuan Li, Ye Chang, Ning Ye, Dongxue Dai, Yintao Chen, Naijin Zhang, Guozhe Sun, Yingxian Sun

Int J Mol Sci. 2017 Feb; 18(2): 436. Published online 2017 Feb 17. doi: 10.3390/ijms18020436

PMCID:: PMC5343970

Abstract Article PDF–9.6M

Select item 513882013.

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention

Sofie M. A. Walenbergh, Tom Houben, Sander S. Rensen, Veerle Bieghs, Tim Hendrikx, Patrick J. van Gorp, Yvonne Oligschlaeger, Mike L. J. Jeurissen, Marion J. J. Gijbels, Wim A. Buurman, Anita C. E. Vreugdenhil, Jan Willem M. Greve, Jogchum Plat, Marten H. Hofker, Satish Kalhan, Jussi Pihlajamäki, Patrick Lindsey, Ger H. Koek, Ronit Shiri-Sverdlov

Sci Rep. 2016; 6: 38278. Published online 2016 Dec 6. doi: 10.1038/srep38278

PMCID:: PMC5138820

Abstract Article PDF–1.0M

Select item 489524314.

Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury

Pasquale Cocchiaro, Christopher Fox, Nicholas W. Tregidgo, Rachel Howarth, Katrina M. Wood, Gerhard R. Situmorang, Luigi M. Pavone, Neil S. Sheerin, Anna Moles

Sci Rep. 2016; 6: 27112. Published online 2016 Jun 7. doi: 10.1038/srep27112

PMCID:: PMC4895243

Abstract Article PDF–3.4M

Select item 463230715.

Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates

E-J Bae, N Y Yang, C Lee, S Kim, H-J Lee, S-J Lee

Cell Death Dis. 2015 Oct; 6(10): e1901. Published online 2015 Oct 8. doi: 10.1038/cddis.2015.283

PMCID:: PMC4632307

Abstract Article PDF–2.7M

Select item 459928616.

Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies

Timo Gemoll, Franziska Epping, Lisa Heinrich, Britta Fritzsche, Uwe J. Roblick, Silke Szymczak, Sonja Hartwig, Reinhard Depping, Hans-Peter Bruch, Christoph Thorns, Stefan Lehr, Andreas Paech, Jens K. Habermann

Oncotarget. 2015 Jun 30; 6(18): 16517–16526. Published online 2015 May 14. doi: 10.18632/oncotarget.4140